25-Hydroxycholesterol suppress IFN-Î³-induced inflammation in microglia by disrupting lipid raft formation and caveolin-mediated signaling endosomes.

Lee, Jee Hoon; Han, Ji-Hye; Woo, Joo Hong; Jou, Ilo

Lee, Jee Hoon; Han, Ji-Hye; Woo, Joo Hong; Jou, Ilo.

Afiliación

Lee JH; Department of Pharmacology, Ajou University School of Medicine, Suwon, South Korea; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, South Korea. Electronic address: if7979@hotmail.com.
Han JH; Department of Pharmacology, Ajou University School of Medicine, Suwon, South Korea; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, South Korea.
Woo JH; Department of Pharmacology, Ajou University School of Medicine, Suwon, South Korea; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, South Korea.
Jou I; Department of Pharmacology, Ajou University School of Medicine, Suwon, South Korea; Inflamm-aging Translational Research Center, Ajou University School of Medicine, Suwon, South Korea. Electronic address: jouilo@aumc.ac.kr.

Free Radic Biol Med ; 179: 252-265, 2022 02 01.

Article en En | MEDLINE | ID: mdl-34808332

Asunto(s)

Hidroxicolesteroles/farmacología; Interferón gamma; Microdominios de Membrana; Microglía; Animales; Caveolinas; Endosomas; Inflamación; Interferón gamma/genética; Ratones Endogámicos C57BL; Enfermedades Neuroinflamatorias

Palabras clave

25-Hydroxycholesterol; Caveolin-1; IFN-Î³; Inflammation; Lipid raft; Microglia; Neurodegenerative diseases; Oxysterols; Signaling endosome

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Interferón gamma / Microglía / Microdominios de Membrana / Hidroxicolesteroles Límite: Animals Idioma: En Revista: Free Radic Biol Med Asunto de la revista: BIOQUIMICA / MEDICINA Año: 2022 Tipo del documento: Article Pais de publicación: Estados Unidos

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