Multiple autoimmunity and epitope spreading in monozygotic twins.
J Transl Autoimmun
; 4: 100132, 2021.
Article
en En
| MEDLINE
| ID: mdl-34816112
We report clinical, serologic, and immunogenetic studies of a set of monozygotic male twin patients who develop autoimmune thyroiditis and vitiligo associated with the HLA-DRB1*04-DQB1*03:02 and HLA-DRB1*03-DQB1*0201 haplotypes. The patients had detectable anti-thyroid and anti-melanocyte autoantibodies. A critical review is presented regarding the role of MHC II molecules linked to clinical manifestations of various autoimmune diseases displayed in a single patient, as is the case in the twin patients reported here.
AMA, anti-mitochondrial antibodies; ANA, antinuclear antibodies; ANCA, antineutrophil cytoplasmic antibodies; ASMA, anti-smooth muscle antibodies; Anti-CCP, anti-cyclic citrullinated peptide antibodies; Anti-GBM, anti-glomerular basement membrane antibodies; Autoimmune diseases; Autoimmunity; BP, bullous pemphigoid; Dsg, desmoglein; Epitope spreading; FITC, fluorescein isothiocyanate; HLA, Human Leucocyte Antigen; HRP, horseradish peroxidase; IgG, immunoglobulin G; MHC, major histocompatibility complex; Multiple autoimmunity; PBS, phosphate buffered saline; SSP, sequence specific priming; TMB, tetramethylbenzidine/H2O2; Thyroiditis; Vitiligo
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
J Transl Autoimmun
Año:
2021
Tipo del documento:
Article
País de afiliación:
México
Pais de publicación:
Países Bajos