FAIRification of nanosafety data to improve applicability of (Q)SAR approaches: A case study on <i>in vitro</i> Comet assay genotoxicity data.

Bossa, Cecilia; Andreoli, Cristina; Bakker, Martine; Barone, Flavia; De Angelis, Isabella; Jeliazkova, Nina; Nymark, Penny; Battistelli, Chiara Laura

FAIRification of nanosafety data to improve applicability of (Q)SAR approaches: A case study on in vitro Comet assay genotoxicity data.

Bossa, Cecilia; Andreoli, Cristina; Bakker, Martine; Barone, Flavia; De Angelis, Isabella; Jeliazkova, Nina; Nymark, Penny; Battistelli, Chiara Laura.

Afiliación

Bossa C; Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Andreoli C; Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Bakker M; Centre for Safety of Substances and Products, National Institute of Public Health and the Environment (RIVM), Bilthoven, the Netherlands.
Barone F; Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
De Angelis I; Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.
Jeliazkova N; Ideaconsult Ltd., Sofia, Bulgaria.
Nymark P; Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.
Battistelli CL; Environment and Health Department, Istituto Superiore di Sanità, Rome, Italy.

Comput Toxicol ; 20: 100190, 2021 Nov.

Article en En | MEDLINE | ID: mdl-34820591

Palabras clave

(Q)SAR approaches; (Q)SAR, (Quantitative) structure-activity relationship; AOP, Adverse Outcome Pathway; ECHA, European Chemicals Agency; FAIR principles; FAIR, Findable, Accessible, Interoperable, and Reusable; Fpg, Formamido pyrimidine glycosilase; Genotoxicity; IATA, Integrated Approaches to Testing and Assessment; ISATab, Investigation/Study/Assay Tab-delimited; JRC, Joint Research Centre; MIRCA, Minimum Information for Reporting Comet Assay; NMBP, Horizon 2020 Advisory Group for Nanotechnologies, Advanced Materials, Biotechnology and Advanced Manufacturing and Processing; NMBP-13-2018 projects, Gov4Nano, NANORIGO and RiskGONE; NMs, nanomaterials; Nano-EHS, Nano Environment, Health and Safety; Nanomaterials; Nanosafety data; OECD, Organisation for Economic Co-operation and Development; OTM, Olive tail moment; REACH, Registration, Evaluation Authorisation and Restriction of Chemicals; SCGE, Single Cell Gel Electrophoresis; SOPs, Standard Operating Procedures; in vitro Comet assay

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Risk_factors_studies Idioma: En Revista: Comput Toxicol Año: 2021 Tipo del documento: Article País de afiliación: Italia

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