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Update on Paraneoplastic Cerebellar Degeneration.
Loehrer, Philipp Alexander; Zieger, Lara; Simon, Ole J.
Afiliación
  • Loehrer PA; Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany.
  • Zieger L; Department of Neurology, University Hospital Gießen and Marburg, 35043 Marburg, Germany.
  • Simon OJ; Department of Neurology, Philipps-University Marburg, 35043 Marburg, Germany.
Brain Sci ; 11(11)2021 Oct 26.
Article en En | MEDLINE | ID: mdl-34827413
Purpose of review: To provide an update on paraneoplastic cerebellar degeneration (PCD), the involved antibodies and tumors, as well as management strategies. Recent findings: PCD represents the second most common presentation of the recently established class of immune mediated cerebellar ataxias (IMCAs). Although rare in general, PCD is one of the most frequent paraneoplastic presentations and characterized clinically by a rapidly progressive cerebellar syndrome. In recent years, several antibodies have been described in association with the clinical syndrome related to PCD; their clinical significance, however, has yet to be determined. The 2021 updated diagnostic criteria for paraneoplastic neurologic symptoms help to establish the diagnosis of PCD, direct cancer screening, and to evaluate the presence of these newly identified antibodies. Recognition of the clinical syndrome and prompt identification of a specific antibody are essential for early detection of an underlying malignancy and initiation of an appropriate treatment, which represents the best opportunity to modulate the course of the disease. As clinical symptoms can precede tumor diagnosis by years, co-occurrence of specific symptoms and antibodies should prompt continuous surveillance of the patient. Summary: We provide an in-depth overview on PCD, summarize recent findings related to PCD, and highlight the transformed diagnostic approach.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: Brain Sci Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies / Screening_studies Idioma: En Revista: Brain Sci Año: 2021 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Suiza