The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with <i>Mycobacterium tuberculosis</i>.

Cahill, Christina; Cox, Dónal J; O'Connell, Fiona; Basdeo, Sharee A; Gogan, Karl M; Ó'Maoldomhnaigh, Cilian; O'Sullivan, Jacintha; Keane, Joseph; Phelan, James J

The Effect of Tuberculosis Antimicrobials on the Immunometabolic Profiles of Primary Human Macrophages Stimulated with Mycobacterium tuberculosis.

Cahill, Christina; Cox, Dónal J; O'Connell, Fiona; Basdeo, Sharee A; Gogan, Karl M; Ó'Maoldomhnaigh, Cilian; O'Sullivan, Jacintha; Keane, Joseph; Phelan, James J.

Afiliación

Cahill C; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
Cox DJ; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
O'Connell F; Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
Basdeo SA; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
Gogan KM; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
Ó'Maoldomhnaigh C; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
O'Sullivan J; Department of Surgery, Trinity Translational Medicine Institute, Trinity College Dublin, St James's Hospital, Dublin 8, Ireland.
Keane J; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.
Phelan JJ; TB Immunology Group, Department of Clinical Medicine, Trinity Translational Medicine Institute, Trinity College, Dublin, Ireland.

Int J Mol Sci ; 22(22)2021 Nov 10.

Article en En | MEDLINE | ID: mdl-34830070

Asunto(s)

Antituberculosos/inmunología; Antituberculosos/farmacología; Macrófagos/inmunología; Macrófagos/metabolismo; Mycobacterium tuberculosis/efectos de los fármacos; Tuberculosis/tratamiento farmacológico; Clofazimina/farmacología; Citocinas/metabolismo; Glucólisis/efectos de los fármacos; Humanos; Lipopolisacáridos/toxicidad; Macrófagos/efectos de los fármacos; Macrófagos/microbiología; Mitocondrias/efectos de los fármacos; Fosforilación Oxidativa/efectos de los fármacos; Cultivo Primario de Células

Palabras clave

antimicrobials; bioenergetics; drug-resistant tuberculosis; glycolysis; host-directed therapy; lipopolysaccharide; mitochondrial function; oxidative phosphorylation; tuberculosis

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tuberculosis / Macrófagos / Mycobacterium tuberculosis / Antituberculosos Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2021 Tipo del documento: Article País de afiliación: Irlanda

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