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B Cell Response Induced by SARS-CoV-2 Infection Is Boosted by the BNT162b2 Vaccine in Primary Antibody Deficiencies.
Pulvirenti, Federica; Fernandez Salinas, Ane; Milito, Cinzia; Terreri, Sara; Piano Mortari, Eva; Quintarelli, Concetta; Di Cecca, Stefano; Lagnese, Gianluca; Punziano, Alessandra; Guercio, Marika; Bonanni, Livia; Auria, Stefania; Villani, Francesca; Albano, Christian; Locatelli, Franco; Spadaro, Giuseppe; Carsetti, Rita; Quinti, Isabella.
Afiliación
  • Pulvirenti F; Regional Reference Centre for Primary Immune Deficiencies, Azienda Ospedaliera Universitaria Policlinico Umberto I, 00185 Rome, Italy.
  • Fernandez Salinas A; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Milito C; Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale di San Paolo, 00146 Rome, Italy.
  • Terreri S; Department of Molecular Medicine, Sapienza University of Rome, 00185 Rome, Italy.
  • Piano Mortari E; Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale di San Paolo, 00146 Rome, Italy.
  • Quintarelli C; Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale di San Paolo, 00146 Rome, Italy.
  • Di Cecca S; Department Onco-Haematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, 00116 Rome, Italy.
  • Lagnese G; Department of Clinical Medicine and Surgery, University of Naples Federico II, 80131 Naples, Italy.
  • Punziano A; Department Onco-Haematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, 00116 Rome, Italy.
  • Guercio M; Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Bonanni L; Department of Translational Medical Sciences, University of Naples Federico II, 80131 Naples, Italy.
  • Auria S; Department Onco-Haematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, 00116 Rome, Italy.
  • Villani F; Regional Reference Centre for Primary Immune Deficiencies, Azienda Ospedaliera Universitaria Policlinico Umberto I, 00185 Rome, Italy.
  • Albano C; Regional Reference Centre for Primary Immune Deficiencies, Azienda Ospedaliera Universitaria Policlinico Umberto I, 00185 Rome, Italy.
  • Locatelli F; Regional Reference Centre for Primary Immune Deficiencies, Azienda Ospedaliera Universitaria Policlinico Umberto I, 00185 Rome, Italy.
  • Spadaro G; Diagnostic Immunology Research Unit, Multimodal Medicine Research Area, Bambino Gesù Children's Hospital, IRCCS, Viale di San Paolo, 00146 Rome, Italy.
  • Carsetti R; Department Onco-Haematology, and Cell and Gene Therapy, Bambino Gesù Children Hospital, IRCCS, 00116 Rome, Italy.
  • Quinti I; Dipartimento Materno-Infantile e Scienze Urologiche, Sapienza University of Rome, 00185 Rome, Italy.
Cells ; 10(11)2021 10 27.
Article en En | MEDLINE | ID: mdl-34831138
BACKGROUND: Patients with primary antibody deficiencies are at risk in the current COVID-19 pandemic due to their impaired response to infection and vaccination. Specifically, patients with common variable immunodeficiency (CVID) generated poor spike-specific antibody and T cell responses after immunization. METHODS: Thirty-four CVID convalescent patients after SARS-CoV-2 infection, 38 CVID patients immunized with two doses of the BNT162b2 vaccine, and 20 SARS-CoV-2 CVID convalescents later and immunized with BNT162b2 were analyzed for the anti-spike IgG production and the generation of spike-specific memory B cells and T cells. RESULTS: Spike-specific IgG was induced more frequently after infection than after vaccination (82% vs. 34%). The antibody response was boosted in convalescents by vaccination. Although immunized patients generated atypical memory B cells possibly by extra-follicular or incomplete germinal center reactions, convalescents responded to infection by generating spike-specific memory B cells that were improved by the subsequent immunization. Poor spike-specific T cell responses were measured independently from the immunological challenge. CONCLUSIONS: SARS-CoV-2 infection primed a more efficient classical memory B cell response, whereas the BNT162b2 vaccine induced non-canonical B cell responses in CVID. Natural infection responses were boosted by subsequent immunization, suggesting the possibility to further stimulate the immune response by additional vaccine doses in CVID.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de Inmunodeficiencia Primaria / SARS-CoV-2 / COVID-19 / Vacuna BNT162 / Células B de Memoria Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Enfermedades de Inmunodeficiencia Primaria / SARS-CoV-2 / COVID-19 / Vacuna BNT162 / Células B de Memoria Límite: Adult / Female / Humans / Male / Middle aged Idioma: En Revista: Cells Año: 2021 Tipo del documento: Article País de afiliación: Italia Pais de publicación: Suiza