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Antibacterial, antioxidant and anti-inflammatory PLCL/gelatin nanofiber membranes to promote wound healing.
Li, Ang; Li, Linhui; Zhao, Bin'an; Li, Xiaotong; Liang, Wencheng; Lang, Meidong; Cheng, Biao; Li, Jun.
Afiliación
  • Li A; Department of Orthopedics, Shanghai Tenth People's Hospital affiliated to Tongji University, 301 Yanchang Road, Shanghai 200072, China; Department of General Surgery, The Affiliated Shanghai Shuguang Hospital of Shanghai University of Traditional Chinese Medicine, 528 Zhangheng Road, Shanghai 201203
  • Li L; Department of Burns, The First Affiliated Hospital of Naval Medical University, No. 168 ChanghaiRoad, Yangpu District, Shanghai 200433, China.
  • Zhao B; Department of Orthopedics, Shanghai Tenth People's Hospital affiliated to Tongji University, 301 Yanchang Road, Shanghai 200072, China.
  • Li X; College of Chemistry, Chemical Engineering and Biotechnology, Donghua University, Shanghai 201620, China.
  • Liang W; Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China.
  • Lang M; Shanghai Key Laboratory of Advanced Polymeric Materials, Key Laboratory for Ultrafine Materials of Ministry of Education, School of Materials Science and Engineering, East China University of Science and Technology, 130 Meilong Road, Shanghai 200237, China. Electronic address: mdlang@ecust.edu.cn.
  • Cheng B; Department of Orthopedics, Shanghai Tenth People's Hospital affiliated to Tongji University, 301 Yanchang Road, Shanghai 200072, China. Electronic address: cbiaoabc@163.com.
  • Li J; Department of Orthopedics, Shanghai Tenth People's Hospital affiliated to Tongji University, 301 Yanchang Road, Shanghai 200072, China. Electronic address: lijunspine@163.com.
Int J Biol Macromol ; 194: 914-923, 2022 Jan 01.
Article en En | MEDLINE | ID: mdl-34838860
ABSTRACT
Epigallocatechin-3-O-gallate (EGCG) is a green biomedical agent for promoting wound healing, which possess excellent antibacterial, antioxidant and anti-inflammatory activities. For improving the low bioavailability challenges of EGCG in vivo, we had successful created a low-cost and simple wound dressing Poly (L-Lactic-co-caprolactone) (PLCL)/Gelatin/EGCG/Core-shell nanofiber membrane (PGEC) with drug sustained release capacity through coaxial electrospinning technology. In vitro experimental indicated that the core-shell structure wound dressing had excellent biocompatibility, antibacterial and antioxidant ability, which could support cell viability and proliferation, encourage re-epithelialization during the healing process, inhibit subsequent wound infection and thus promote wound regeneration. In vivo experimental demonstrated that PGEC wound dressing could promote wound healing, the histological results further demonstrated that PGEC not only facilitated early wound closure but also influenced cellular differentiation and tissue organization. Meanwhile, PGEC had excellent hemostatic ability. Taken all together, we believed that the PGEC wound dressing, which could localize delivery of EGCG, had high potential clinical application for promoting wound healing, hemostasis or other related clinical applications in the future.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Nanofibras / Gelatina / Membranas Artificiales / Antiinflamatorios / Antibacterianos / Antioxidantes Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Cicatrización de Heridas / Nanofibras / Gelatina / Membranas Artificiales / Antiinflamatorios / Antibacterianos / Antioxidantes Límite: Animals Idioma: En Revista: Int J Biol Macromol Año: 2022 Tipo del documento: Article