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The impact of diabetic neuropathy on the distal versus proximal comparison of weakness in lower and upper limb muscles of patients with type 2 diabetes mellitus: a cross-sectional study.
Van Eetvelde, Birgit L M; Lapauw, Bruno; Proot, Pascal; Vanden Wyngaert, Karsten; Helleputte, Simon; Stautemas, Jan; Cambier, Dirk C; Calders, Patrick.
Afiliación
  • Van Eetvelde BLM; Department of Rehabilitation Sciences, Ghent University, Belgium.
  • Lapauw B; Department of Endocrinology, Ghent University Hospital, Belgium.
  • Proot P; Department of Neurology, Ghent University Hospital, Belgium.
  • Vanden Wyngaert K; Department of Rehabilitation Sciences, Ghent University, Belgium.
  • Helleputte S; Department of Rehabilitation Sciences, Ghent University, Belgium.
  • Stautemas J; Department of Rehabilitation Sciences, Ghent University, Belgium.
  • Cambier DC; Department of Rehabilitation Sciences, Ghent University, Belgium.
  • Calders P; Department of Rehabilitation Sciences, Ghent University, Belgium.
J Musculoskelet Neuronal Interact ; 21(4): 464-474, 2021 12 01.
Article en En | MEDLINE | ID: mdl-34854385
OBJECTIVES: This study aimed to determine the impact of diabetic neuropathy (dNP) on the distal versus proximal comparison of weakness in lower and upper limb muscles of patients with type 2 Diabetes Mellitus (T2DM). METHODS: 19 healthy male controls without neuropathy (HC) and 35 male T2DM patients, without dNP (n=8), with sensory dNP (n=13) or with sensorimotor dNP (dNPsm; n=14), were enrolled in this study. Maximal isometric (IM) and isokinetic (IK) muscle strength and IK muscle endurance of the dominant knee, ankle and elbow, and maximal IM handgrip strength were measured by means of dynamometry. RESULTS: Ankle muscle endurance was lower compared to the knee, independently of dNP (p<0.001). Maximal IK ankle muscle strength was also lower compared to the knee, albeit only in dNPsm (p=0.003). No differences were found between maximal IM handgrip and elbow strength. CONCLUSIONS: Our results suggest an impact of T2DM -with or without dNP- on lower limb muscle strength more distally than proximally, while this was not observed in the upper limb. The gradient of dNP seemed to be a determining factor for the maximal muscle strength, and not for muscle endurance, in the lower limb.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: J Musculoskelet Neuronal Interact Asunto de la revista: FISIOLOGIA / NEUROLOGIA / ORTOPEDIA Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Grecia

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Mellitus Tipo 2 / Neuropatías Diabéticas Tipo de estudio: Observational_studies / Prevalence_studies / Risk_factors_studies Límite: Humans / Male Idioma: En Revista: J Musculoskelet Neuronal Interact Asunto de la revista: FISIOLOGIA / NEUROLOGIA / ORTOPEDIA Año: 2021 Tipo del documento: Article País de afiliación: Bélgica Pais de publicación: Grecia