On-Bone Fixation of Free Gingival Graft Induces an Osteoinductive Effect in Human Alveolar Bone.
Bull Exp Biol Med
; 172(2): 276-281, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34855081
ABSTRACT
We examined alveolar bone samples in the area of on-bone fixation of a free gingival graft performed during surgery in patients aged 37-55 years with a diagnosis of secondary partial adentia of the upper and lower jaws. Six months after fixation of the graft in the alveolar bone, foci of neoosteogenesis were found in the contact zone. They were characterized by the appearance of appositional lines, cords of basophilic osteoblasts, and growing osteons. An immunohistochemical study revealed an increase in the number of CD44+, CD29+, and osteocalcin+ cells in the layer of the outer circumferential lamellae, primary osteons, and the lining of the Haversian canals. TGF-ß1+ cells were located in the intertrabecular reticular tissue and wall of microvessels. The results indicate activation of mesenchymal stem cells in the area of localization of the graft and differentiating osteoblasts. The observed osteoinductive effect of free gingival graft is associated with its participation in reorganization in MSC and induction of morphogenetic molecules.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Oseointegración
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Arcada Parcialmente Edéntula
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Implantación Dental
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Proceso Alveolar
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Encía
Límite:
Adult
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Female
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Humans
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Male
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Middle aged
Idioma:
En
Revista:
Bull Exp Biol Med
Año:
2021
Tipo del documento:
Article
País de afiliación:
Rusia