Development of electrospun mats based on hydrophobic hydroxypropyl cellulose derivatives.
Mater Sci Eng C Mater Biol Appl
; 131: 112498, 2021 Dec.
Article
en En
| MEDLINE
| ID: mdl-34857284
In this work, hydroxypropyl cellulose esters (HPCE) with long aliphatic chains were prepared and innovatively used in electrospinning to obtain hydroxypropyl cellulose (HPC)-based mats with enhanced resistance to moist environments. The described approach is very simple and does not require any post-treatment (e.g. cross-linking step) to overcome a major problem concerning the premature loss of properties of cellulose-based materials when in contact with moisture. HPCE-based electrospun mats were characterized in terms of their morphology, swelling ability and in vitro hydrolytic degradation. The mats exhibited a swelling capacity of over 115%, depending on the degree of substitution. The in vitro hydrolytic degradation tests showed the high structural integrity of the mats (< 5% weight loss) over a period of 30 days. The in vitro cytotoxicity tests showed that the mats of HPC esters are cytocompatible and promote the adhesion, proliferation and spreading of NIH3T3 fibroblast cells. These data suggest that the HPCE mats may be interesting materials for wound dressings, as well as for other tissue engineering applications.
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Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Nanofibras
Límite:
Animals
Idioma:
En
Revista:
Mater Sci Eng C Mater Biol Appl
Año:
2021
Tipo del documento:
Article
País de afiliación:
Portugal
Pais de publicación:
Países Bajos