Blood withdrawal acutely impairs cardiac filling, output and aerobic capacity in proportion to induced hypovolemia in middle-aged and older women.
Appl Physiol Nutr Metab
; : 1-8, 2021 Dec 08.
Article
en En
| MEDLINE
| ID: mdl-34875180
ABSTRACT
Blood donation entails acute reductions of cardiorespiratory fitness in healthy men. Whether these effects can be extrapolated to blood donor populations comprising women remains uncertain. The purpose of this study was to comprehensively assess the acute impact of blood withdrawal on cardiac function, central hemodynamics and aerobic capacity in women throughout the mature adult lifespan. Transthoracic echocardiography and O2 uptake were assessed at rest and throughout incremental exercise (cycle ergometry) in healthy women (n = 30, age 47-77 yr). Left ventricular end-diastolic volume (LVEDV), stroke volume (SV), cardiac output (QÌ) and peak O2 uptake (VÌO2peak), and blood volume (BV) were determined with established methods. Measurements were repeated following a 10% reduction of BV within a week period. Individuals were non-smokers, non-obese and moderately fit (VÌO2peak = 31.4 ± 7.3 mL·min-1·kg-1). Hematocrit and BV ranged from 38.0 to 44.8% and from 3.8 to 6.6 L, respectively. The standard 10% reduction in BV resulted in 0.5 ± 0.1 L withdrawal of blood, which did not alter hematocrit (P = 0.953). Blood withdrawal substantially reduced cardiac LVEDV and SV at rest as well as during incremental exercise (≥10% decrements, P ≤ 0.009). Peak QÌ was proportionally decreased after blood withdrawal (P < 0.001). Blood withdrawal induced a 10% decrement in VÌO2peak (P < 0.001). In conclusion, blood withdrawal impairs cardiac filling, QÌ and aerobic capacity in proportion to the magnitude of hypovolemia in healthy mature women. Novelty The filling of the heart and therefore cardiac output are impaired by blood withdrawal in women. Oxygen delivery and aerobic capacity are reduced in proportion to blood withdrawal.
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1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Appl Physiol Nutr Metab
Asunto de la revista:
CIENCIAS DA NUTRICAO
/
FISIOLOGIA
/
MEDICINA ESPORTIVA
/
METABOLISMO
Año:
2021
Tipo del documento:
Article
País de afiliación:
Canadá