Bruceine D inhibits HIF-1<i>&#945;</i>-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/<i>ß</i>-catenin interaction.

Huang, Rui; Zhang, Lijun; Jin, Jinmei; Zhou, Yudong; Zhang, Hongwei; Lv, Chao; Lu, Dong; Wu, Ye; Zhang, Hong; Liu, Sanhong; Chen, Hongzhuan; Luan, Xin; Zhang, Weidong

Bruceine D inhibits HIF-1α-mediated glucose metabolism in hepatocellular carcinoma by blocking ICAT/ß-catenin interaction.

Huang, Rui; Zhang, Lijun; Jin, Jinmei; Zhou, Yudong; Zhang, Hongwei; Lv, Chao; Lu, Dong; Wu, Ye; Zhang, Hong; Liu, Sanhong; Chen, Hongzhuan; Luan, Xin; Zhang, Weidong.

Afiliación

Huang R; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang L; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Jin J; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhou Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang H; Department of Chemistry and Biochemistry, College of Liberal Arts, University of Mississippi, University, MS 38677-1848, USA.
Lv C; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Lu D; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Wu Y; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Liu S; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Chen H; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Luan X; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.
Zhang W; Institute of Interdisciplinary Integrative Medicine Research, Shanghai University of Traditional Chinese Medicine, Shanghai 201203, China.

Acta Pharm Sin B ; 11(11): 3481-3492, 2021 Nov.

Article en En | MEDLINE | ID: mdl-34900531

Palabras clave

BD, bruceine D; Bruceine D; CETSA, cellular thermal shift assay; Cyt c, cytochrome c; DARTS, drug affinity responsive target stability; HCC, hepatocellular carcinoma; HIF-1α; HIF-1α, hypoxia-inducible factor-1α; HIF-1ß, hypoxia-inducible factor-1ß; Hepatocellular carcinoma; Hypoxia; ICAT; ICAT, inhibitor of ß-catenin and T-cell factor; MST, microscale thermophoresis; Metabolism; ROS, reactive oxygen species; Tumor microenvironment; ß-Catenin

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Prognostic_studies Idioma: En Revista: Acta Pharm Sin B Año: 2021 Tipo del documento: Article País de afiliación: China

Texto completo

Añadir a Mi BVS

Imprimir

XML

PubMed Links

Buscar en Google