The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells.

Azevedo Portilho, Nathalia; Saini, Deepak; Hossain, Ishtiaque; Sirois, Jacinthe; Moraes, Christopher; Pastor, William A

The DNMT1 inhibitor GSK-3484862 mediates global demethylation in murine embryonic stem cells.

Azevedo Portilho, Nathalia; Saini, Deepak; Hossain, Ishtiaque; Sirois, Jacinthe; Moraes, Christopher; Pastor, William A.

Afiliación

Azevedo Portilho N; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Saini D; Department of Chemical Engineering, McGill University, Montreal, QC, H3A 0C5, Canada.
Hossain I; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Sirois J; The Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada.
Moraes C; Department of Biochemistry, McGill University, Montreal, QC, H3G 1Y6, Canada.
Pastor WA; The Rosalind and Morris Goodman Cancer Institute, McGill University, Montreal, QC, H3A 1A3, Canada.

Epigenetics Chromatin ; 14(1): 56, 2021 12 15.

Article en En | MEDLINE | ID: mdl-34906184

Asunto(s)

ADN (Citosina-5-)-Metiltransferasas; Células Madre Embrionarias; Animales; Azacitidina/toxicidad; ADN (Citosina-5-)-Metiltransferasas/genética; ADN (Citosina-5-)-Metiltransferasas/metabolismo; Metilación de ADN; Desmetilación; Células Madre Embrionarias/metabolismo; Ratones

Palabras clave

5-Azacytidine; DNA methylation; DNMT1; Decitabine; Demethylation; GSK-3484862; GSK-3685032; Whole-genome bisulfite sequencing

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: ADN (Citosina-5-)-Metiltransferasas / Células Madre Embrionarias Límite: Animals Idioma: En Revista: Epigenetics Chromatin Año: 2021 Tipo del documento: Article País de afiliación: Canadá Pais de publicación: Reino Unido

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