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Assessment of Markers of Gut Integrity and Inflammation in Non-Celiac Gluten Sensitivity After a Gluten Free-Diet.
Dale, Hanna Fjeldheim; Johannessen, Julianne C H; Brønstad, Ingeborg; Lied, Gülen Arslan.
Afiliación
  • Dale HF; Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
  • Johannessen JCH; Division of Gastroenterology, Department of Medicine, Haukeland University Hospital, Bergen, Norway.
  • Brønstad I; National Centre of Functional Gastrointestinal Disorders, Haukeland University Hospital, Bergen, Norway.
  • Lied GA; Centre for Nutrition, Department of Clinical Medicine, University of Bergen, Bergen, Norway.
Int J Gen Med ; 14: 9459-9470, 2021.
Article en En | MEDLINE | ID: mdl-34916830
PURPOSE: Markers for gut integrity and inflammation have received increasing interest as intestinal permeability and innate immune system activation are suggested as possible pathophysiological mechanisms in non-celiac gluten sensitivity (NCGS). We aimed to assess relevant biomarkers in NCGS by analyzing serum levels of gut integrity and permeability markers, pro-inflammatory cytokines and antigliadin IgG in patients with suspected NCGS on a gluten-free diet (GFD), and compare them to serum levels in patients with irritable bowel syndrome (IBS) and healthy controls (HC). PATIENTS AND METHODS: Serum samples collected from patients with suspected NCGS on a GFD (n=20, 14 women, 21-62 years), IBS (n=20, 16 women, 24-67 years) and HC (n=20, 14 women, 21-54 years) were analyzed. IBS severity scoring system (IBS-SSS) was applied to evaluate gastrointestinal symptoms. RESULTS: The IBS-SSS score was higher in subjects with suspected NCGS and IBS patients compared to HC (p<0.0001). No significant differences were found in the serum levels of any of the gut integrity and permeability markers, cytokines or antigliadin IgG antibodies between the three groups. However, positive correlations were observed between claudin-1 and i-FABP, and between claudin-1 and antigliadin IgG antibodies. CONCLUSION: No differences in serum levels of gut integrity and permeability markers, pro-inflammatory cytokines or antigliadin IgG antibodies were found among patients with suspected NCGS on a GFD, IBS and HC.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Int J Gen Med Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Nueva Zelanda

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Tipo de estudio: Diagnostic_studies Idioma: En Revista: Int J Gen Med Año: 2021 Tipo del documento: Article País de afiliación: Noruega Pais de publicación: Nueva Zelanda