Vicinal Difunctionalization of Alkenes Using Vinyl Triflates Leading to γ-Trifluoromethylated Ketones.

ABSTRACT

We report a new methodology for the synthesis of γ-trifluoromethylated ketones from alkenes and vinyl triflate bifunctional reagents. The reaction proceeds via the addition of a ß-trifluoromethyl alkyl radical to a vinyl triflate, followed by ß-cleavage. We also demonstrate a one-pot version of the reaction for the vicinal functionalization of alkenes from alkynes.