Vicinal Difunctionalization of Alkenes Using Vinyl Triflates Leading to γ-Trifluoromethylated Ketones.
Org Lett
; 24(1): 324-327, 2022 Jan 14.
Article
en En
| MEDLINE
| ID: mdl-34918932
ABSTRACT
We report a new methodology for the synthesis of γ-trifluoromethylated ketones from alkenes and vinyl triflate bifunctional reagents. The reaction proceeds via the addition of a ß-trifluoromethyl alkyl radical to a vinyl triflate, followed by ß-cleavage. We also demonstrate a one-pot version of the reaction for the vicinal functionalization of alkenes from alkynes.
Texto completo:
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Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Lett
Asunto de la revista:
BIOQUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Japón