Perfluorochemicals as gastrointestinal contrast agents for MR imaging: preliminary studies in rats and humans.
AJR Am J Roentgenol
; 148(6): 1259-63, 1987 Jun.
Article
en En
| MEDLINE
| ID: mdl-3495156
ABSTRACT
The ability to distinguish bowel from other intraabdominal structures is essential for the accurate diagnosis of intraabdominal disease with MR. Because perfluorochemicals have no protons, they cause no MR signal. Since they are immiscible with water, they create a signal void in bowel independent of bowel contents and thus are suitable as oral contrast agents. Furthermore, they are tasteless and odorless and have no side effects. We evaluated the use of perfluorochemicals by performing MR scans of the abdomen in rats after the oral administration of unemulsified perfluorohexylbromide or perfluoroctylbromide. Since the latter is approved as an investigational drug for oral use in humans, two volunteers were also studied. Both compounds created signal void in the bowel of both rats and human subjects allowing identification of the gastrointestinal tract. The results suggest that these compounds have potential as oral contrast agents for MR imaging.
Buscar en Google
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Espectroscopía de Resonancia Magnética
/
Medios de Contraste
/
Sistema Digestivo
/
Fluorocarburos
Límite:
Animals
/
Humans
Idioma:
En
Revista:
AJR Am J Roentgenol
Año:
1987
Tipo del documento:
Article