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Clinical outcomes, Kadish-INSICA staging and therapeutic targeting of somatostatin receptor 2 in olfactory neuroblastoma.
Lechner, Matt; Takahashi, Yoko; Turri-Zanoni, Mario; Liu, Jacklyn; Counsell, Nicholas; Hermsen, Mario; Kaur, Raman Preet; Zhao, Tianna; Ramanathan, Murugappan; Schartinger, Volker H; Emanuel, Oscar; Helman, Sam; Varghese, Jordan; Dudas, Jozsef; Riechelmann, Herbert; Sprung, Susanne; Haybaeck, Johannes; Howard, David; Engel, Nils Wolfgang; Stewart, Sarah; Brooks, Laura; Pickles, Jessica C; Jacques, Thomas S; Fenton, Tim R; Williams, Luke; Vaz, Francis M; O'Flynn, Paul; Stimpson, Paul; Wang, Simon; Hannan, S Alam; Unadkat, Samit; Hughes, Jonathan; Dwivedi, Raghav; Forde, Cillian T; Randhawa, Premjit; Gane, Simon; Joseph, Jonathan; Andrews, Peter J; Royle, Gary; Franchi, Alessandro; Maragliano, Roberta; Battocchio, Simonetta; Bewicke-Copley, Helen; Pipinikas, Christodoulos; Webster, Amy; Thirlwell, Chrissie; Ho, Debbie; Teschendorff, Andrew; Zhu, Tianyu; Steele, Christopher D.
Afiliación
  • Lechner M; UCL Cancer Institute, University College London, London, UK; Academic Head and Neck Centre, UCL Division of Surgery and Interventional Science, University College London, London, UK; ENT Department, Barts Health NHS Trust, London, United Kingdom; Rhinology & Endoscopic Skull Base Surgery, Depart
  • Takahashi Y; Department of Head and Neck Surgery, The University of Texas MD Anderson Cancer Center, Houston, USA.
  • Turri-Zanoni M; Unit of Otorhinolaryngology and Head & Neck Surgery, Department of Biotechnology and Life Sciences, ASST Sette Laghi, University of Insubria, Varese, Italy.
  • Liu J; UCL Cancer Institute, University College London, London, UK.
  • Counsell N; Cancer Research UK & UCL Cancer Trials Centre, University College London, London, UK.
  • Hermsen M; Department of Head and Neck Oncology, Instituto de Investigacio´n Sanitaria Del Principado de Asturias (ISPA), Instituto Universitario de Oncologi´a Del Principado de Asturias (IUOPA), Centro de Investigacio´n Biome´dica en Red (CIBER-ONC), Oviedo, Spain.
  • Kaur RP; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA.
  • Zhao T; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA.
  • Ramanathan M; Department of Otolaryngology - Head and Neck Surgery, Johns Hopkins School of Medicine, Baltimore, USA.
  • Schartinger VH; Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
  • Emanuel O; UCL Cancer Institute, University College London, London, UK.
  • Helman S; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
  • Varghese J; Department of Otolaryngology-Head and Neck Surgery, Emory University School of Medicine, Atlanta, USA.
  • Dudas J; Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
  • Riechelmann H; Department of Otorhinolaryngology, Medical University of Innsbruck, Innsbruck, Austria.
  • Sprung S; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria.
  • Haybaeck J; Institute of Pathology, Neuropathology and Molecular Pathology, Medical University of Innsbruck, Innsbruck, Austria; Diagnostic & Research Center for Molecular BioMedicine, Institute of Pathology, Medical University Graz, Graz, Austria.
  • Howard D; Head and Neck Cancer Unit, Imperial College Healthcare NHS Trust, London, UK.
  • Engel NW; Department of Oncology, Haematology and Bone Marrow Transplantation with Section Pneumology, Hubertus Wald Tumorzentrum, University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
  • Stewart S; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Brooks L; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Pickles JC; Department of Developmental Biology and Cancer & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Jacques TS; Department of Developmental Biology and Cancer & Teaching Department, UCL Great Ormond Street Institute of Child Health, London, UK; Department of Histopathology, Great Ormond Street Hospital for Children NHS Foundation Trust, London, UK.
  • Fenton TR; School of Biosciences, University of Kent, Canterbury, UK; School of Cancer Sciences, Faculty of Medicine, University of Southampton, Southampton, UK.
  • Williams L; UCL Division of Surgery and Interventional Science, University College London, London, UK.
  • Vaz FM; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • O'Flynn P; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Stimpson P; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Wang S; Institute of Nuclear Medicine, University College London, London, UK.
  • Hannan SA; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Unadkat S; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Hughes J; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Dwivedi R; Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Forde CT; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Randhawa P; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Gane S; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Joseph J; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Andrews PJ; Royal National Ear, Nose and Throat Hospital and Head and Neck Centre, University College London Hospitals NHS Trust, London, UK.
  • Royle G; UCL Cancer Institute, University College London, London, UK.
  • Franchi A; Department of Translational Research, University of Pisa, Pisa, Italy.
  • Maragliano R; Department of Medicine and Surgery, Unit of Pathology, University of Insubria, Varese, Italy.
  • Battocchio S; Pathology Unit, Department of Molecular and Translational Medicine, University of Brescia, ASST Spedali Civili, Brescia, Italy.
  • Bewicke-Copley H; UCL Cancer Institute, University College London, London, UK.
  • Pipinikas C; UCL Cancer Institute, University College London, London, UK.
  • Webster A; UCL Cancer Institute, University College London, London, UK.
  • Thirlwell C; UCL Cancer Institute, University College London, London, UK; College of Medicine and Health and Institute of Biomedical and Clinical Science, University of Exeter, Exeter, UK.
  • Ho D; Stem Cell Institute, University of Cambridge, Cambridge, UK.
  • Teschendorff A; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China.
  • Zhu T; CAS Key Laboratory of Computational Biology, Shanghai Institute of Nutrition and Health, University of Chinese Academy of Sciences, Shanghai, China.
  • Steele CD; Department of Neurosurgery, Johns Hopkins University School of Medicine, Baltimore, USA.
Eur J Cancer ; 162: 221-236, 2022 02.
Article en En | MEDLINE | ID: mdl-34980502
INTRODUCTION: Olfactory neuroblastoma (ONB) is a rare cancer of the sinonasal region. We provide a comprehensive analysis of this malignancy with molecular and clinical trial data on a subset of our cohort to report on the potential efficacy of somatostatin receptor 2 (SSTR2)-targeting imaging and therapy. METHODS: We conducted a retrospective analysis of 404 primary, locally recurrent, and metastatic olfactory neuroblastoma (ONB) patients from 12 institutions in the United States of America, United Kingdom and Europe. Clinicopathological characteristics and treatment approach were evaluated. SSTR2 expression, SSTR2-targeted imaging and the efficacy of peptide receptor radionuclide therapy [PRRT](177Lu-DOTATATE) were reported in a subset of our cohort (LUTHREE trial; NCT03454763). RESULTS: Dural infiltration at presentation was a significant predictor of overall survival (OS) and disease-free survival (DFS) in primary cases (n = 278). Kadish-Morita staging and Dulguerov T-stage both had limitations regarding their prognostic value. Multivariable survival analysis demonstrated improved outcomes with lower stage and receipt of adjuvant radiotherapy. Prophylactic neck irradiation significantly reduces the rate of nodal recurrence. 82.4% of the cohort were positive for SSTR2; treatment of three metastatic cases with SSTR2-targeted peptide-radionuclide receptor therapy (PRRT) in the LUTHREE trial was well-tolerated and resulted in stable disease (SD). CONCLUSIONS: This study presents pertinent clinical data from the largest dataset, to date, on ONB. We identify key prognostic markers and integrate these into an updated staging system, highlight the importance of adjuvant radiotherapy across all disease stages, the utility of prophylactic neck irradiation and the potential efficacy of targeting SSTR2 to manage disease.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Nasales / Estesioneuroblastoma Olfatorio / Neuroblastoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Cancer Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias Nasales / Estesioneuroblastoma Olfatorio / Neuroblastoma Tipo de estudio: Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Humans Idioma: En Revista: Eur J Cancer Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido