Modelling the association between biomarkers and clinical outcome: An introduction to nonlinear joint models.
Br J Clin Pharmacol
; 88(4): 1452-1463, 2022 02.
Article
en En
| MEDLINE
| ID: mdl-34993985
ABSTRACT
Nonlinear joint models are a powerful tool to precisely analyse the association between a nonlinear biomarker and a time-to-event process, such as death. Here, we review the main methodological techniques required to build these models and to make inferences and predictions. We describe the main clinical applications and discuss the future developments of such models.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Modelos Estadísticos
/
Dinámicas no Lineales
Tipo de estudio:
Prognostic_studies
/
Risk_factors_studies
Límite:
Humans
Idioma:
En
Revista:
Br J Clin Pharmacol
Año:
2022
Tipo del documento:
Article
País de afiliación:
Francia