A new nanosuspension prepared with wet milling method for oral delivery of highly variable drug Cyclosporine A: development, optimization and in vivo evaluation.

Pinar, Sila Gülbag; Canpinar, Hande; Tan, Çagman; Çelebi, Nevin

Pinar, Sila Gülbag; Canpinar, Hande; Tan, Çagman; Çelebi, Nevin.

Afiliación

Pinar SG; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Etiler, 06330, Yenimahalle, Ankara, Turkey; Süleyman Demirel University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 32260, Çünür, Isparta, Turkey.
Canpinar H; Hacettepe University, Cancer Institute, Department of Basic Oncology, 06100, Sihhiye, Ankara, Turkey.
Tan Ç; Hacettepe University, Faculty of Medicine, Institute of Child Health, 06100, Sihhiye, Ankara, Turkey.
Çelebi N; Gazi University, Faculty of Pharmacy, Department of Pharmaceutical Technology, Etiler, 06330, Yenimahalle, Ankara, Turkey; Baskent University, Faculty of Pharmacy, Department of Pharmaceutical Technology, 06790, Etimesgut, Ankara, Turkey. Electronic address: fncelebi@baskent.edu.tr.

Eur J Pharm Sci ; 171: 106123, 2022 Apr 01.

Article en En | MEDLINE | ID: mdl-35017012

Asunto(s)

Ciclosporina; Nanopartículas; Administración Oral; Animales; Disponibilidad Biológica; Nanopartículas/química; Tamaño de la Partícula; Ratas; Solubilidad; Suspensiones

Palabras clave

Cyclosporine a; Dissolution; Nanosuspension; Pharmacokinetic; T lymphocyte subsets; Top-down technology

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ciclosporina / Nanopartículas Límite: Animals Idioma: En Revista: Eur J Pharm Sci Asunto de la revista: FARMACIA / FARMACOLOGIA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Turquía Pais de publicación: Países Bajos

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