Zika virus baculovirus-expressed envelope protein elicited humoral and cellular immunity in immunocompetent mice.
Sci Rep
; 12(1): 660, 2022 01 13.
Article
en En
| MEDLINE
| ID: mdl-35027643
ABSTRACT
Zika virus (ZIKV) is a mosquito-borne virus that has a high risk of inducing Guillain-Barré syndrome and microcephaly in newborns. Because vaccination is considered the most effective strategy against ZIKV infection, we designed a recombinant vaccine utilizing the baculovirus expression system with two strains of ZIKV envelope protein (MR766, Env_M; ZBRX6, Env_Z). Animals inoculated with Env_M and Env_Z produced ZIKV-specific antibodies and secreted effector cytokines such as interferon-γ, tumor necrosis factor-α, and interleukin-12. Moreover, the progeny of immunized females had detectable maternal antibodies that protected them against two ZIKV strains (MR766 and PRVABC59) and a Dengue virus strain. We propose that the baculovirus expression system ZIKV envelope protein recombinant provides a safe and effective vaccine strategy.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Vacunas Virales
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Vacunas Sintéticas
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Proteínas del Envoltorio Viral
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Baculoviridae
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Inmunidad Humoral
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Virus Zika
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Infección por el Virus Zika
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Inmunidad Celular
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Inmunocompetencia
Límite:
Animals
Idioma:
En
Revista:
Sci Rep
Año:
2022
Tipo del documento:
Article