Association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes in a US population: A cross-sectional study.
Medicine (Baltimore)
; 101(2): e28568, 2022 Jan 14.
Article
en En
| MEDLINE
| ID: mdl-35029227
ABSTRACT
ABSTRACT Various heavy metal elements in the human body have been reported to be associated with dyslipidemia, hypertension, and diabetes. The role of cobalt in these conditions is unclear. The current study aimed to investigate the association of blood cobalt concentrations with dyslipidemia, hypertension, and diabetes.Using the data collected from the National Health and Nutrition Examination Survey (2015-2018), we performed logistic regression to explore the association of blood cobalt concentrations with total cholesterol (TC), low-density lipoprotein cholesterol (LDL-C), high-density lipoprotein cholesterol (HDL-C), triglycerides, hypertension, and diabetes.A total of 6866 adults were included in this study. Participants with higher blood cobalt levels appeared to be older and have a lower body mass index and, were more likely to be female (P for trendâ<â.05). After fully adjusting for demographic characteristics (Model 2), compared with the lowest quartile, the highest quartile of blood cobalt concentrations had lower odds ratios (ORs) for elevated TC [OR 0.62, 95% confidential interval (CI) 0.53 to 0.72, Pâ<â.001], elevated LDL-C (OR 0.65, 95% CI 0.53-0.80, Pâ<â.001) and low HDL-C (OR 0.81, 95% CI 0.69-0.96, Pâ=â.013). The adjusted ORs for elevated TC, elevated LDL-C and low HDL-C were negatively correlated with increased blood cobalt concentrations (P for trendâ<â.05). The adjusted ORs for hypertension and diabetes were not associated with blood cobalt concentrations (Pâ>â.05 and P for trendâ>â.05).In conclusion, higher blood cobalt concentrations were associated with a lower risk of dyslipidemia. However, blood cobalt concentrations were not associated with the risk of hypertension or diabetes.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Cobalto
/
Diabetes Mellitus
/
Dislipidemias
/
Hipertensión
Tipo de estudio:
Etiology_studies
/
Observational_studies
/
Prevalence_studies
/
Prognostic_studies
/
Risk_factors_studies
Límite:
Adult
/
Female
/
Humans
/
Male
País/Región como asunto:
America do norte
Idioma:
En
Revista:
Medicine (Baltimore)
Año:
2022
Tipo del documento:
Article
País de afiliación:
China