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Nitazoxanide and related thiazolides induce cell death in cancer cells by targeting the 20S proteasome with novel binding modes.
Lü, Zirui; Li, Xiaona; Li, Kebin; Ripani, Paola; Shi, Xiaomeng; Xu, Fengrong; Wang, Mopei; Zhang, Liangren; Brunner, Thomas; Xu, Ping; Niu, Yan.
Afiliación
  • Lü Z; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China.
  • Li X; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China.
  • Li K; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China.
  • Ripani P; Biochemical Pharmacology, Department of Biology, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany.
  • Shi X; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China.
  • Xu F; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China.
  • Wang M; Department of Tumor Chemotherapy and Radiation Sickness, Peking University Third Hospital, Beijing 100191, China.
  • Zhang L; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China; State Key Laboratory of Natural and Biomimetic Drugs, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China.
  • Brunner T; Biochemical Pharmacology, Department of Biology, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany; Konstanz Research School Chemical Biology, University of Konstanz, Universitätsstr. 10, 78457 Konstanz, Germany.
  • Xu P; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China. Electronic address: pingxu@bjmu.edu.cn.
  • Niu Y; Department of Medicinal Chemistry, School of Pharmaceutical Sciences, Peking University Health Science Center, Xueyuan Road 38, Beijing 100191, China. Electronic address: yanniu@bjmu.edu.cn.
Biochem Pharmacol ; 197: 114913, 2022 03.
Article en En | MEDLINE | ID: mdl-35032461
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazoles / Sistemas de Liberación de Medicamentos / Muerte Celular / Complejo de la Endopetidasa Proteasomal / Inhibidores de Proteasoma / Antineoplásicos / Nitrocompuestos Límite: Animals / Humans / Male Idioma: En Revista: Biochem Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Tiazoles / Sistemas de Liberación de Medicamentos / Muerte Celular / Complejo de la Endopetidasa Proteasomal / Inhibidores de Proteasoma / Antineoplásicos / Nitrocompuestos Límite: Animals / Humans / Male Idioma: En Revista: Biochem Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido