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Relationship between time-dependent variability in cardiometabolic risk factors and biochemical markers with cytokine and adipokine levels in hemodialysis patients.
Ribeiro, Anderson Castro; Silva, Robson Eugênio; Justino, Patrícia Braga Issa; Santos, Eliziária Cardoso; Gonçalves, Reggiani Vilela; Novaes, Rômulo Dias.
Afiliación
  • Ribeiro AC; School of Medicine, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; University Hospital Alzira Velano, Alfenas 37132-202, Minas Gerais, Brazil.
  • Silva RE; School of Medicine, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil; University Hospital Alzira Velano, Alfenas 37132-202, Minas Gerais, Brazil.
  • Justino PBI; University Hospital Alzira Velano, Alfenas 37132-202, Minas Gerais, Brazil.
  • Santos EC; School of Medicine, Federal University of Jequitinhonha and Mucuri Valleys, Diamantina 39100-000, Minas Gerais, Brazil.
  • Gonçalves RV; Department of Animal Biology, Federal University of Viçosa, Viçosa 36570-000, Minas Gerais, Brazil.
  • Novaes RD; Institute of Biomedical Sciences, Federal University of Alfenas, Alfenas 37130-001, Minas Gerais, Brazil. Electronic address: romulo.novaes@unifal-mg.edu.br.
Cytokine ; 151: 155802, 2022 03.
Article en En | MEDLINE | ID: mdl-35051728
Hemodialysis patients (HP) are exposed to malnutrition, cardiometabolic and pro-inflammatory risk factors. However, limited knowledge of the variability of these risk factors remains a serious barrier to the proper clinical management of HP. From a longitudinal study, we investigated the relationship between time-dependent variability in cardiometabolic risk factors and biochemical markers with cytokine and adipokine circulating levels in HP. Thirty-eight HP (women = 15, men = 23) aged 54.13 ± 16.78 years old underwent three independent anthropometric, nutritional, biochemical and immunological assessments (1, 6 and 12 months). Patient's characteristics (body mass, comorbidities, history of kidney disease and time on hemodialysis) were similar after sex stratification. From grouped data, 31.6-100.0% HP exhibited multiple malnutrition and cardiometabolic risk factors in all time-points evaluated. All anthropometric and nutritional results, and most biochemical markers were similar in 1, 6 and 12 months follow-up, indicating a marked time-dependent stability. Urea, creatinine, total proteins, albumin, adipokines (adiponectin, leptin and resistin) and cytokines (TNF, IL-6 and IL-10) levels were highly variable in 12 months follow-up. Direct correlations between leptin and fat mass, TNF and IL-6 with creatinine and pre-dialysis urea were observed in all time-points (1, 6 and 12 months). Creatinine and pre-dialysis urea were negatively correlated with IL-10 for the entire follow-up. Fat mass, creatinine and pre-dialysis urea were predictive markers of leptin, TNF, IL-6 and IL-10 variability. Our findings indicated that biochemical, nutritional and cardiovascular risk factors exhibit low time-dependent variability in HP under clinical and nutritional monitoring. However, adipokines and cytokines are highly variables, which can potentially be influenced by body adiposity, creatinine and urea clearance. Thus, these parameters can contribute to predict the inflammatory status in HP.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Adipoquinas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Citocinas / Adipoquinas Tipo de estudio: Etiology_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Revista: Cytokine Asunto de la revista: ALERGIA E IMUNOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Brasil Pais de publicación: Reino Unido