Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-&#954;B.

Huang, Wei-Chieh; Hou, Shaw-Min; Wu, Ming-Ping; Hsia, Chih-Wei; Jayakumar, Thanasekaran; Hsia, Chih-Hsuan; Bhavan, Periyakali Saravana; Chung, Chi-Li; Sheu, Joen-Rong

Decreased Human Platelet Activation and Mouse Pulmonary Thrombosis by Rutaecarpine and Comparison of the Relative Effectiveness with BAY11-7082: Crucial Signals of p38-NF-κB.

Huang, Wei-Chieh; Hou, Shaw-Min; Wu, Ming-Ping; Hsia, Chih-Wei; Jayakumar, Thanasekaran; Hsia, Chih-Hsuan; Bhavan, Periyakali Saravana; Chung, Chi-Li; Sheu, Joen-Rong.

Afiliación

Huang WC; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hou SM; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Wu MP; Department of Cardiovascular Center, Cathay General Hospital, Taipei 106, Taiwan.
Hsia CW; School of Medicine, College of Medicine, Fu Jen Catholic University, New Taipei City 242, Taiwan.
Jayakumar T; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Hsia CH; Division of Urogynecology, Department of Obstetrics and Gynecology, Chi Mei Medical Center, Tainan 710, Taiwan.
Bhavan PS; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Chung CL; Graduate Institute of Medical Sciences, College of Medicine, Taipei Medical University, Taipei 110, Taiwan.
Sheu JR; Translational Medicine Center, Shin Kong Wu Ho-Su Memorial Hospital, Taipei 111, Taiwan.

Molecules ; 27(2)2022 Jan 12.

Article en En | MEDLINE | ID: mdl-35056795

Asunto(s)

Fibrinolíticos/farmacología; Alcaloides Indólicos/farmacología; FN-kappa B/metabolismo; Nitrilos/farmacología; Quinazolinas/farmacología; Sulfonas/farmacología; Trombosis/tratamiento farmacológico; Trombosis/metabolismo; Proteínas Quinasas p38 Activadas por Mitógenos/metabolismo; Animales; Modelos Animales de Enfermedad; Fibrinolíticos/uso terapéutico; Depuradores de Radicales Libres/farmacología; Depuradores de Radicales Libres/uso terapéutico; Radicales Libres/antagonistas & inhibidores; Humanos; Quinasa I-kappa B/antagonistas & inhibidores; Imidazoles/farmacología; Imidazoles/uso terapéutico; Alcaloides Indólicos/uso terapéutico; Masculino; Ratones Endogámicos ICR; FN-kappa B/antagonistas & inhibidores; Nitrilos/uso terapéutico; Selectina-P/metabolismo; Activación Plaquetaria/efectos de los fármacos; Inhibidores de Proteínas Quinasas/farmacología; Inhibidores de Proteínas Quinasas/uso terapéutico; Embolia Pulmonar/tratamiento farmacológico; Embolia Pulmonar/metabolismo; Piridinas/farmacología; Piridinas/uso terapéutico; Quinazolinas/uso terapéutico; Sulfonas/uso terapéutico; Factor de Transcripción ReIA/metabolismo

Palabras clave

DPPH; NF-κB; human platelets; p38 MAPK; pulmonary thrombosis; rutaecarpine

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Quinazolinas / Sulfonas / Trombosis / FN-kappa B / Alcaloides Indólicos / Proteínas Quinasas p38 Activadas por Mitógenos / Fibrinolíticos / Nitrilos Tipo de estudio: Prognostic_studies Límite: Animals / Humans / Male Idioma: En Revista: Molecules Asunto de la revista: BIOLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: Suiza

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