Evaluation of the toxicity of glucocorticoids in patients with autoimmune blistering disease using the Glucocorticoid Toxicity Index: A cohort study.
JAAD Int
; 6: 68-76, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-35059661
ABSTRACT
BACKGROUND:
Glucocorticoids are the mainstay of treatment for autoimmune blistering diseases (AIBDs). The Glucocorticoid Toxicity Index (GTI) is a novel, outcome-based glucocorticoid-induced adverse effects monitoring instrument.OBJECTIVE:
To investigate whether the GTI score was able to accurately quantify the glucocorticoid-induced toxicity in patients with AIBDs.METHODS:
The prospective cohort study included patients with confirmed diagnoses of AIBDs (group1, currently receiving glucocorticoids; and group 2, had glucocorticoids ceased earlier). Data were collected minimally at baseline (V1) and 3 months (V2). Further data from patients who were able to complete the follow-up visits at 6 months (V3) and 12 months (V4) amid the COVID-19 pandemic were also included. GTI scores were calculated after data collection.RESULTS:
Analysis of data from V1 and V2 found a linear correlation between GTI score and prednisone doses (P < .05) and a significant difference in GTI scores between group1 and group 2 (P < .05). Data from V3 and V4 suggested that GTI scores continued to rise progressively alongside increasing cumulative prednisone dose.LIMITATIONS:
Small sample size, further exacerbated by the COVID-19 pandemic. Single-center study.CONCLUSION:
The GTI sensitively and specifically captured the changes in glucocorticoids toxicity over time among patients with AIBDs. The GTI could be a feasible tool that can be used in future clinical trials as a glucocorticoid-induced toxicity outcome measure.
ABQOL, Autoimmune Bullous Disease Quality of Life; AIBD, autoimmune blistering disease; Autoimmune blistering disease; BMI, body mass index; GCAE, glucocorticoid-induced adverse effect; GTI, Glucocorticoid Toxicity Index; GTI-AIS, Glucocorticoid Toxicity Index Aggregate Improvement Score; GTI-CWS, Glucocorticoid Toxicity Index Cumulative Worsening Score; Glucocorticoid Toxicity Index; clinical research; glucocorticoid; side effect
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Tipo de estudio:
Etiology_studies
/
Observational_studies
Aspecto:
Patient_preference
Idioma:
En
Revista:
JAAD Int
Año:
2022
Tipo del documento:
Article
País de afiliación:
Australia