Evolution of anti-SARS-CoV-2 immune response in a cohort of French healthcare workers followed for 7 months.
Infect Dis Now
; 52(2): 68-74, 2022 Mar.
Article
en En
| MEDLINE
| ID: mdl-35063702
ABSTRACT
OBJECTIVES:
We aimed to understand the immune response among healthcare workers (HCWs) following SARS-CoV-2 infection, and to determine the infection prevalence during the first wave of the pandemic among workers in our hospital.METHODS:
Determination of the serological status against SARS-CoV-2 (nucleocapsid) was offered to all HCWs. All HCWs with positive SARS-CoV-2 serology were proposed to be included in a longitudinal medical and serological follow-up (anti-spike) for 7months.RESULTS:
We included 3062 HCWs; 256 (8.4%) were positive for anti-SARS-CoV-2 nucleocapsid IgG. Among them, early decrease in the anti-nucleocapsid antibody index was observed between the first (S1) and second (S2) serology samplings in 208 HCWs (84.2%). The initial anti-nucleocapsid IgG index seemed to be related to the HCWs' age. Seventy-four HCWs were included in the 7-month cohort study. Among them, 69 (90.5%) had detectable anti-spike IgG after 7months and 24 (32.4%) reported persistent symptoms consistent with post-acute COVID-19 syndrome diagnosis.CONCLUSION:
The prevalence of serological positivity among HCWs was 6.7%. Infection should be followed by vaccination because of antibody decrease.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Personal de Salud
/
COVID-19
/
Anticuerpos Antivirales
Tipo de estudio:
Etiology_studies
/
Incidence_studies
/
Observational_studies
/
Risk_factors_studies
Límite:
Humans
País/Región como asunto:
Europa
Idioma:
En
Revista:
Infect Dis Now
Año:
2022
Tipo del documento:
Article