Durable response to durvalumab-based immunochemotherapy in small-cell lung carcinoma transformation from EGFR-mutant non-small cell lung cancer: A case report.
Thorac Cancer
; 13(5): 775-779, 2022 03.
Article
en En
| MEDLINE
| ID: mdl-35088537
ABSTRACT
Combined small-cell lung carcinoma (C-SCLC) is small-cell lung carcinoma (SCLC) with added non-small-cell morphology. We report a case of epidermal growth factor receptor (EGFR) mutation-positive C-SCLC in an 84-year-old patient with metastatic brain lesions who developed intrinsic resistance to osimertinib, a tyrosine kinase inhibitor (TKI). The patient was diagnosed with small-cell transformation of non-small-cell lung carcinoma (NSCLC) and received 6 cycles of dose-adjusted durvalumab with etoposide and carboplatin. In December 2021, the patient received the seventeenth cycle of maintenance durvalumab 19 months after diagnosis and showed continued treatment response and disease control. Comprehensive molecular profiling and repeated biopsies are recommended in NSCLC patients who progress on first-line EGFR-TKIs. Durvalumab in combination with chemotherapy appears to be beneficial for EGFR mutation-positive C-SCLC patients that are resistant to TKIs.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Carcinoma
/
Carcinoma de Pulmón de Células no Pequeñas
/
Neoplasias Pulmonares
Tipo de estudio:
Diagnostic_studies
Límite:
Aged80
/
Humans
Idioma:
En
Revista:
Thorac Cancer
Año:
2022
Tipo del documento:
Article
País de afiliación:
China