Effects of real-ambient PM2.5 exposure plus lipopolysaccharide on multiple organ damage in mice.
Hum Exp Toxicol
; 41: 9603271211061505, 2022.
Article
en En
| MEDLINE
| ID: mdl-35098763
ABSTRACT
Background:
The toxicological effects of fine particulate matter (PM2.5) on the cardiopulmonary and nervous systems have been studied widely, whereas the study of PM2.5 on systemic toxicity is not in-depth enough. Lipopolysaccharide (LPS) can cause multiple organ damage. The combined effects of co-exposure of PM2.5 plus LPS on the stomach, spleen, intestine, and kidney are still unclear.Purpose:
This study was aimed to explore the toxicological effects of co-exposure of PM2.5 and LPS on the different organs of mice. Research Design and Study Sample Using a real-ambient PM2.5 exposure system and an intraperitoneal LPS injection mouse model, we investigated multiple organ damage effects on male BALB/c mice after co-exposure of PM2.5 plus LPS for 23 weeks in Linfen, a city with a high PM2.5 concentration in China. Data Collection Eosin-hematoxylin staining, ELISA and the biochemical assay analysed the toxicological effects.Results:
The pathological tissue injury on the four organs above appeared in mice co-exposed to PM2.5 plus LPS, accompanied by the body weight and stomach organ coefficient abnormality, and significant elevation of pro-inflammatory cytokines levels, oxidative stress in the spleen and kidney, and levels of kidney injury molecule (KIM-1) increase in the kidney. There were tissue differences in the pathological damage and toxicological effects on mice after co-exposure, in which the spleen and kidney were more sensitive to pollutants. In the PM2.5 + LPS group, the superoxide dismutase inhibition and catalase (CAT) activity promotion in the kidney or spleen of mice were significant relative to the PM2.5 group; the CAT and interleukin-6 (IL-6) levels in the spleen were raised considerably compared with the LPS group.Conclusions:
These findings suggested the severity and sensitivity of multiple organ injuries in mice in response to PM2.5 plus LPS.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Enfermedades del Bazo
/
Gastropatías
/
Lipopolisacáridos
/
Material Particulado
/
Enfermedades Intestinales
/
Enfermedades Renales
/
Insuficiencia Multiorgánica
Tipo de estudio:
Prognostic_studies
Límite:
Animals
/
Humans
/
Male
País/Región como asunto:
Asia
Idioma:
En
Revista:
Hum Exp Toxicol
Asunto de la revista:
TOXICOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
China