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IgA Nephropathy with Gross Hematuria Following COVID-19 mRNA Vaccination.
Nihei, Yoshihito; Kishi, Monami; Suzuki, Hitoshi; Koizumi, Ayako; Yoshida, Maiko; Hamaguchi, Sho; Iwasaki, Masako; Fukuda, Hiromitsu; Takahara, Hisatsugu; Kihara, Masao; Tomita, Shigeki; Suzuki, Yusuke.
Afiliación
  • Nihei Y; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Kishi M; Department of Human Pathology, Juntendo University School of Medicine, Japan.
  • Suzuki H; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Koizumi A; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Yoshida M; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Hamaguchi S; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Iwasaki M; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Fukuda H; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Takahara H; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Kihara M; Department of Nephrology, Juntendo University Urayasu Hospital, Japan.
  • Tomita S; Department of Nephrology, Juntendo University Faculty of Medicine, Japan.
  • Suzuki Y; Department of Human Pathology, Juntendo University School of Medicine, Japan.
Intern Med ; 61(7): 1033-1037, 2022 Apr 01.
Article en En | MEDLINE | ID: mdl-35110484
ABSTRACT
A 28-year-old woman experienced gross hematuria after the administration of the second dose of an messenger ribonucleic acid (mRNA) vaccine (BNT162b2). She was diagnosed with Immunogloblin A nephropathy (IgAN) by a renal biopsy two weeks after vaccination, which revealed a mild increase in mesangial cells and a matrix with co-depositions of galactose-deficient IgA1 and C3 in the mesangial region. The gross hematuria and proteinuria gradually improved without any medication, suggesting that immune activation by the mRNA vaccine may not elicit continuous disease progression of IgAN. Thus, further studies investigating the relationship between mRNA vaccines against COVID-19 and the progression of IgAN should be conducted.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Glomerulonefritis por IGA Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adult / Female / Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2022 Tipo del documento: Article País de afiliación: Japón
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: COVID-19 / Glomerulonefritis por IGA Tipo de estudio: Diagnostic_studies / Etiology_studies Límite: Adult / Female / Humans Idioma: En Revista: Intern Med Asunto de la revista: MEDICINA INTERNA Año: 2022 Tipo del documento: Article País de afiliación: Japón