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Lab-on-a-Contact Lens: Recent Advances and Future Opportunities in Diagnostics and Therapeutics.
Zhu, Yangzhi; Li, Shaopei; Li, Jinghang; Falcone, Natashya; Cui, Qingyu; Shah, Shilp; Hartel, Martin C; Yu, Ning; Young, Patric; de Barros, Natan Roberto; Wu, Zhuohong; Haghniaz, Reihaneh; Ermis, Menekse; Wang, Canran; Kang, Heemin; Lee, Junmin; Karamikamkar, Solmaz; Ahadian, Samad; Jucaud, Vadim; Dokmeci, Mehmet R; Kim, Han-Jun; Khademhosseini, Ali.
Afiliación
  • Zhu Y; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Li S; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Li J; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Falcone N; School of Engineering, Westlake University, Hangzhou, Zhejiang Province, 310024, China.
  • Cui Q; School of Materials Science and Engineering, Wuhan Institute of Technology, Wuhan, Hubei Province, 430205, China.
  • Shah S; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Hartel MC; Department of Medicine, David Geffen School of Medicine, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
  • Yu N; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Young P; Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
  • de Barros NR; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Wu Z; Department of Bioengineering, University of California-Los Angeles, Los Angeles, CA, 90095, USA.
  • Haghniaz R; Department of Chemical and Environmental Engineering, University of California-Riverside, Riverside, CA, 92521, USA.
  • Ermis M; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Wang C; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Kang H; Department of Nanoengineering, University of California-San Diego, San Diego, CA, 92093, USA.
  • Lee J; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Karamikamkar S; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Ahadian S; Andrew and Peggy Cherng Department of Medical Engineering, Division of Engineering and Applied Science, California Institute of Technology, Pasadena, CA, 91125, USA.
  • Jucaud V; Department of Materials Science and Engineering, Korea University, Seoul, 02841, Republic of Korea.
  • Dokmeci MR; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
  • Kim HJ; Department of Materials Science and Engineering, Pohang University of Science and Technology (POSTECH), Pohang, 37673, Republic of Korea.
  • Khademhosseini A; Terasaki Institute for Biomedical Innovation, Los Angeles, CA, 90064, USA.
Adv Mater ; 34(24): e2108389, 2022 Jun.
Article en En | MEDLINE | ID: mdl-35130584
The eye is one of the most complex organs in the human body, containing rich and critical physiological information (e.g., intraocular pressure, corneal temperature, and pH) as well as a library of metabolite biomarkers (e.g., glucose, proteins, and specific ions). Smart contact lenses (SCLs) can serve as a wearable intelligent ocular prosthetic device capable of noninvasive and continuous monitoring of various essential physical/biochemical parameters and drug loading/delivery for the treatment of ocular diseases. Advances in SCL technologies and the growing public interest in personalized health are accelerating SCL research more than ever before. Here, the current status and potential of SCL development through a comprehensive review from fabrication to applications to commercialization are discussed. First, the material, fabrication, and platform designs of the SCLs for the diagnostic and therapeutic applications are discussed. Then, the latest advances in diagnostic and therapeutic SCLs for clinical translation are reviewed. Later, the established techniques for wearable power transfer and wireless data transmission applied to current SCL devices are summarized. An outlook, future opportunities, and challenges for developing next-generation SCL devices are also provided. With the rise in interest of SCL development, this comprehensive and essential review can serve as a new paradigm for the SCL devices.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lentes de Contacto Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania
Texto completo
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Lentes de Contacto Tipo de estudio: Diagnostic_studies Límite: Humans Idioma: En Revista: Adv Mater Asunto de la revista: BIOFISICA / QUIMICA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Alemania