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Neuroinflammation as potential precursor of leukoencephalopathy in early-stage breast cancer patients: A cross-sectional PET-MRI study.
Schroyen, Gwen; Sleurs, Charlotte; Bartsoen, Emilie; Smeets, Dirk; van Weehaeghe, Donatienne; Van Laere, Koen; Smeets, Ann; Deprez, Sabine; Sunaert, Stefan.
Afiliación
  • Schroyen G; Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, 3000, Leuven, Belgium.
  • Sleurs C; Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium; Department of Oncology, KU Leuven, 3000, Leuven, Belgium. Electronic address: charlotte.sleurs@kuleuven.be.
  • Bartsoen E; Department of Oncology, KU Leuven, 3000, Leuven, Belgium.
  • Smeets D; icometrix, 3012, Leuven, Belgium.
  • van Weehaeghe D; Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium; Department of Nuclear Medicine and Molecular Imaging, KU Leuven, 3000, Leuven, Belgium.
  • Van Laere K; Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, 3000, Leuven, Belgium; Nuclear Medicine, University Hospitals Leuven, 3000, Leuven, Belgium; Department of Nuclear Medicine and Molecul
  • Smeets A; Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium; Department of Oncology, KU Leuven, 3000, Leuven, Belgium; Surgical Oncology, University Hospitals Leuven, 3000, Leuven, Belgium.
  • Deprez S; Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium; Leuven Cancer Institute, KU Leuven, 3000, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, 3000, Leuven, Belgium.
  • Sunaert S; Leuven Brain Institute, KU Leuven, 3000, Leuven, Belgium; Department of Imaging and Pathology, KU Leuven, 3000, Leuven, Belgium; Radiology, University Hospitals Leuven, 3000, Leuven, Belgium.
Breast ; 62: 61-68, 2022 Apr.
Article en En | MEDLINE | ID: mdl-35131644
ABSTRACT

BACKGROUND:

Although chemotherapy-induced leukoencephalopathy has been described in case and cohort studies, literature remains inconclusive about its prevalence and mechanisms. Therefore, we investigated the presence of leukoencephalopathy after multiagent chemotherapy in women treated for breast cancer and potential underlying neuroinflammatory processes.

METHODS:

In this exploratory study, 15 chemotherapy-treated and 15 age-matched chemotherapy-naïve patients with early-stage breast cancer, as well as 15 healthy controls underwent simultaneous PET-MR neuroimaging, including T1-weighted MPRAGE, T2-weighted FLAIR and dynamic PET with the 18-kDA translocator protein (TSPO) radioligand [18F]DPA-714. Total and regional (juxtacortical, periventricular, deep white matter and infratentorial) lesion burden were compared between the groups with one-way ANOVA. With paired t-tests, [18F]DPA-714 volume of distribution [VT, including partial volume correction (PVC)] in lesioned and normal appearing white matter (NAWM) were compared within subjects, to investigate inflammation. Finally, two general linear models were used to examine the predictive values of neurofilament light-chain (NfL) serum levels on (1) total lesion burden or (2) PVC [18F]DPA-714 VT of lesions showing elevated inflammation.

RESULTS:

No significant differences were found in total or localized lesion burden. However, significantly higher (20-45%) TSPO uptake was observed in juxtacortical lesions (p ≤ 0.008, t ≥ 3.90) compared to NAWM in both cancer groups, but only persisted for chemotherapy-treated patients after PVC (p = 0.005, t = 4.30). NfL serum levels were not associated with total lesion volume or tracer uptake in juxtacortical lesions.

CONCLUSION:

This multimodal neuroimaging study suggests that neuroinflammatory processes could be involved in the development of juxtacortical, but not periventricular or deep white matter, leukoencephalopathy shortly after chemotherapy for early-stage breast cancer.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Leucoencefalopatías Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: Bélgica

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Leucoencefalopatías Tipo de estudio: Observational_studies / Prevalence_studies / Prognostic_studies Límite: Female / Humans Idioma: En Revista: Breast Asunto de la revista: ENDOCRINOLOGIA / NEOPLASIAS Año: 2022 Tipo del documento: Article País de afiliación: Bélgica