Use of In Vitro Human Skin Models to Assess Potential Immune Activation In Response to Biotherapeutic Attributes and Process-related Impurities.

Tokuda, Joshua M; Xie, Jiansong; Jawa, Vibha; Hawkins, Jenn M; Ferbas, John; Joh, Nathan H; Joubert, Marisa K

Tokuda, Joshua M; Xie, Jiansong; Jawa, Vibha; Hawkins, Jenn M; Ferbas, John; Joh, Nathan H; Joubert, Marisa K.

Afiliación

Tokuda JM; Amgen Inc, Thousand Oaks, California 91320, USA. Electronic address: jtokuda@amgen.com.
Xie J; Amgen Inc, Thousand Oaks, California 91320, USA.
Jawa V; Bristol-Myers Squibb Pharmaceuticals Ltd, Lawrence Township, New Jersey 08648, USA.
Hawkins JM; Amgen Inc, Thousand Oaks, California 91320, USA.
Ferbas J; Amgen Inc, Thousand Oaks, California 91320, USA.
Joh NH; Amgen Inc, Thousand Oaks, California 91320, USA. Electronic address: nate.joh@amgen.com.
Joubert MK; Amgen Inc, Thousand Oaks, California 91320, USA. Electronic address: mjoubert@amgen.com.

J Pharm Sci ; 111(4): 1012-1023, 2022 04.

Article en En | MEDLINE | ID: mdl-35139332

Asunto(s)

Citocinas; Piel; Anticuerpos; Citocinas/metabolismo; Humanos; Inmunoterapia; Inyecciones Subcutáneas; Piel/metabolismo

Palabras clave

Aggregates; Biologics; Biotherapeutics; Cytokines; Engineered skin; Immune response; Impurities; Monoclonal antibodies; Subcutaneous

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Piel / Citocinas Límite: Humans Idioma: En Revista: J Pharm Sci Año: 2022 Tipo del documento: Article

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