Manganese(II) EOB-Pyclen Diacetate for Liver-Specific MRI.
ACS Appl Bio Mater
; 5(2): 451-458, 2022 02 21.
Article
en En
| MEDLINE
| ID: mdl-35148050
ABSTRACT
MRI is increasingly utilized for the diagnosis of liver disease and focal liver lesions. Although liver-targeted gadolinium-based contrast agents (GBCAs) have high efficacy, there continue to be safety concerns regarding release of toxic Gd(III) ions. Herein, Mn(EOB-PC2A) is synthesized as a nongadolinium alternative for liver-specific MRI. Mn(EOB-PC2A) has an r1 relaxivity of 2.8 mM-1 s-1 in Dulbecco's phosphate-buffered saline (DPBS) and 5.9 mM-1 s-1 in saline containing human serum albumin at 1.5 T. It has a strong uptake in hepatocytes with minimal toxicity and demonstrated robust liver-specific enhancement at a dose of 60 µmol/kg. Mn(EOB-PC2A) is a promising liver-specific contrast agent for liver MRI.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Gadolinio DTPA
/
Manganeso
Límite:
Humans
Idioma:
En
Revista:
ACS Appl Bio Mater
Año:
2022
Tipo del documento:
Article
País de afiliación:
Estados Unidos