Inhibition of the Na<sup>+</sup>/K<sup>+</sup>-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation.

Shandell, Mia A; Capatina, Alina L; Lawrence, Samantha M; Brackenbury, William J; Lagos, Dimitris

Inhibition of the Na⁺/K⁺-ATPase by cardiac glycosides suppresses expression of the IDO1 immune checkpoint in cancer cells by reducing STAT1 activation.

Shandell, Mia A; Capatina, Alina L; Lawrence, Samantha M; Brackenbury, William J; Lagos, Dimitris.

Afiliación

Shandell MA; Department of Biology, University of York, York, United Kingdom; Hull York Medical School, University of York, York, United Kingdom; York Biomedical Research Institute, University of York, York, United Kingdom.
Capatina AL; Department of Biology, University of York, York, United Kingdom; York Biomedical Research Institute, University of York, York, United Kingdom.
Lawrence SM; Department of Biology, University of York, York, United Kingdom.
Brackenbury WJ; Department of Biology, University of York, York, United Kingdom; York Biomedical Research Institute, University of York, York, United Kingdom.
Lagos D; Hull York Medical School, University of York, York, United Kingdom; York Biomedical Research Institute, University of York, York, United Kingdom. Electronic address: dimitris.lagos@york.ac.uk.

J Biol Chem ; 298(3): 101707, 2022 03.

Article en En | MEDLINE | ID: mdl-35150740

Asunto(s)

Glicósidos Cardíacos; Indolamina-Pirrol 2,3,-Dioxigenasa; Neoplasias; Factor de Transcripción STAT1; ATPasa Intercambiadora de Sodio-Potasio; Células A549; Glicósidos Cardíacos/farmacología; Línea Celular Tumoral; Digoxina/farmacología; Humanos; Proteínas de Punto de Control Inmunitario; Indolamina-Pirrol 2,3,-Dioxigenasa/antagonistas & inhibidores; Indolamina-Pirrol 2,3,-Dioxigenasa/biosíntesis; Quinurenina/metabolismo; Neoplasias/patología; Ouabaína/metabolismo; Ouabaína/farmacología; Factor de Transcripción STAT1/metabolismo; ATPasa Intercambiadora de Sodio-Potasio/antagonistas & inhibidores; ATPasa Intercambiadora de Sodio-Potasio/metabolismo

Palabras clave

ATP1A1; IDO1; digoxin; immune checkpoints; ouabain; sodium transport; tumor ionic microenvironment

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glicósidos Cardíacos / ATPasa Intercambiadora de Sodio-Potasio / Indolamina-Pirrol 2,3,-Dioxigenasa / Factor de Transcripción STAT1 / Neoplasias Tipo de estudio: Prognostic_studies Límite: Humans Idioma: En Revista: J Biol Chem Año: 2022 Tipo del documento: Article País de afiliación: Reino Unido Pais de publicación: Estados Unidos

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