Your browser doesn't support javascript.
loading
The German Gestational Diabetes Study (PREG), a prospective multicentre cohort study: rationale, methodology and design.
Fritsche, Louise; Hummel, Julia; Wagner, Robert; Löffler, Dorina; Hartkopf, Julia; Machann, Jürgen; Hilberath, Johannes; Kantartzis, Konstantinos; Jakubowski, Peter; Pauluschke-Fröhlich, Jan; Brucker, Sara; Hörber, Sebastian; Häring, Hans-Ulrich; Roden, Michael; Schürmann, Annette; Solimena, Michele; de Angelis, Martin Hrabe; Peter, Andreas; Birkenfeld, Andreas L; Preissl, Hubert; Fritsche, Andreas; Heni, Martin.
Afiliación
  • Fritsche L; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany louise.fritsche@med.uni-tuebingen.de.
  • Hummel J; German Center for Diabetes Research, Neuherberg, Germany.
  • Wagner R; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
  • Löffler D; German Center for Diabetes Research, Neuherberg, Germany.
  • Hartkopf J; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
  • Machann J; German Center for Diabetes Research, Neuherberg, Germany.
  • Hilberath J; Department for Diabetology, Endocrinology, and Nephrology, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Kantartzis K; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
  • Jakubowski P; German Center for Diabetes Research, Neuherberg, Germany.
  • Pauluschke-Fröhlich J; Department for Diabetology, Endocrinology, and Nephrology, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Brucker S; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
  • Hörber S; German Center for Diabetes Research, Neuherberg, Germany.
  • Häring HU; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
  • Roden M; German Center for Diabetes Research, Neuherberg, Germany.
  • Schürmann A; Section on Experimental Radiology, Department of Diagnostic and Interventional Radiology, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Solimena M; Department for Pediatric Gastroenterology and Hepatology, Faculty of Medicine, Eberhard Karls University Tübingen, Tübingen, Germany.
  • de Angelis MH; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
  • Peter A; German Center for Diabetes Research, Neuherberg, Germany.
  • Birkenfeld AL; Department of Women's Health, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Preissl H; Department of Women's Health, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Fritsche A; Department of Women's Health, Eberhard Karls University Tübingen, Tübingen, Germany.
  • Heni M; Institute of Diabetes Research and Metabolic Diseases, Helmholtz Center Munich German Research Center for Environmental Health, Tübingen, Germany.
BMJ Open ; 12(2): e058268, 2022 Feb 15.
Article en En | MEDLINE | ID: mdl-35168986
INTRODUCTION: Even well-treated gestational diabetes mellitus (GDM) might still have impact on long-term health of the mother and her offspring, although this relationship has not yet been conclusively studied. Using in-depth phenotyping of the mother and her offspring, we aim to elucidate the relationship of maternal hyperglycaemia during pregnancy and adequate treatment, and its impact on the long-term health of both mother and child. METHODS: The multicentre PREG study, a prospective cohort study, is designed to metabolically and phenotypically characterise women with a 75-g five-point oral glucose tolerance test (OGTT) during, and repeatedly after pregnancy. Outcome measures are maternal glycaemia during OGTTs, birth outcome and the health and growth development of the offspring. The children of the study participants are followed up until adulthood with developmental tests and metabolic and epigenetic phenotyping in the PREG Offspring study. A total of 800 women (600 with GDM, 200 controls) will be recruited. ETHICS AND DISSEMINATION: The study protocol has been approved by all local ethics committees. Results will be disseminated via conference presentations and peer-reviewed publications. TRIAL REGISTRATION NUMBER: The PREG study and the PREG Offspring study are registered with Clinical Trials (ClinicalTrials.gov identifiers: NCT04270578, NCT04722900).
Asunto(s)
Palabras clave

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Gestacional Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Observational_studies Aspecto: Ethics Límite: Adult / Child / Female / Humans / Male / Pregnancy Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Diabetes Gestacional Tipo de estudio: Clinical_trials / Etiology_studies / Guideline / Observational_studies Aspecto: Ethics Límite: Adult / Child / Female / Humans / Male / Pregnancy Idioma: En Revista: BMJ Open Año: 2022 Tipo del documento: Article País de afiliación: Alemania Pais de publicación: Reino Unido