Synthesis of Deuterated Heterocycles with Me<sub>2</sub>NCD(OMe)<sub>2</sub> and Evaluation of the Products for Metabolism by Aldehyde Oxidase.

Choi, Chulho; Carlo, Anthony A; Cronin, Ciarán N; Jing, Konghua; Kung, Daniel W; Liu, Jianhua; Lombardo, Vincent M; Turco, Abigail R; Yin, Juxing; Yu, Aijia; Wright, Stephen W

Synthesis of Deuterated Heterocycles with Me₂NCD(OMe)₂ and Evaluation of the Products for Metabolism by Aldehyde Oxidase.

Choi, Chulho; Carlo, Anthony A; Cronin, Ciarán N; Jing, Konghua; Kung, Daniel W; Liu, Jianhua; Lombardo, Vincent M; Turco, Abigail R; Yin, Juxing; Yu, Aijia; Wright, Stephen W.

Afiliación

Choi C; Medicine Design, Pfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.
Carlo AA; Structural Biology and Protein Sciences, Pfizer Worldwide Research, Development and Medical, La Jolla, California 92121, United States.
Cronin CN; Structural Biology and Protein Sciences, Pfizer Worldwide Research, Development and Medical, La Jolla, California 92121, United States.
Jing K; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Kung DW; Medicine Design, Pfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.
Liu J; Structural Biology and Protein Sciences, Pfizer Worldwide Research, Development and Medical, La Jolla, California 92121, United States.
Lombardo VM; Medicine Design, Pfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.
Turco AR; Medicine Design, Pfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.
Yin J; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Yu A; WuXi AppTec, 288 Fute Zhong Road, Waigaoqiao Free Trade Zone, Shanghai 200131, China.
Wright SW; Medicine Design, Pfizer Worldwide Research, Development and Medical, Eastern Point Road, Groton, Connecticut 06340, United States.

ACS Med Chem Lett ; 13(2): 250-256, 2022 Feb 10.

Article en En | MEDLINE | ID: mdl-35178182

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: ACS Med Chem Lett Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos

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