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Combinatory effects of current regimens and Guizhi Fuling Wan on the development of endometriosis.
Chen, Chih-Chen; Huang, Chun-Yen; Shiu, Li-Yen; Yu, Ya-Chun; Lai, Jui-Chi; Chang, Chi-Chang; Fu, Chi-Feng; Huang, S Joseph.
Afiliación
  • Chen CC; Department of Obstetrics and Gynecology, E-Da Hospital, Kaohsiung, Taiwan.
  • Huang CY; Department of Obstetrics and Gynecology, E-Da Hospital, Kaohsiung, Taiwan; Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan.
  • Shiu LY; Center for Cell Therapy, E-Da Cancer Hospital, Kaohsiung, Taiwan; Center for Cell Therapy, E-Da Hospital, Kaohsiung, Taiwan.
  • Yu YC; Department of Obstetrics and Gynecology, E-Da Hospital, Kaohsiung, Taiwan; Department of Medical Research, E-Da Hospital, Kaohsiung, Taiwan.
  • Lai JC; Center for Cell Therapy, E-Da Cancer Hospital, Kaohsiung, Taiwan.
  • Chang CC; Department of Obstetrics and Gynecology, E-Da Da-Chang Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan.
  • Fu CF; Department of Obstetrics and Gynecology, E-Da Cancer Hospital, Kaohsiung, Taiwan. Electronic address: ed102146@edah.org.tw.
  • Huang SJ; Department of Obstetrics and Gynecology, E-Da Hospital, Kaohsiung, Taiwan; School of Medicine, College of Medicine, I-Shou University, Kaohsiung, Taiwan; Department of Obstetrics and Gynecology, Morsani College of Medicine, University of South Florida, Tampa, FL, USA. Electronic address: ed108566@ed
Taiwan J Obstet Gynecol ; 61(1): 70-74, 2022 Jan.
Article en En | MEDLINE | ID: mdl-35181049
OBJECTIVE: Endometriosis, defined as the growth of endometrial glands and stromal cells in a heterotopic location under the cyclic influence of ovarian hormones, is a common gynecological disorder manifested by chronic pelvic pain and infertility. In traditional Chinese medicine, endometriosis is characterized by stagnation of vital energy (qi) and blood stasis. Guizhi Fuling Wan (GFW) was first described in Chinese canonical medicine to treat disorders associated with stagnation of qi and blood stasis, including endometriosis. Therefore, the current study aimed to test the effects of combining GFW with western medicine on the suppression of endometriosis. MATERIALS AND METHODS: Endometriosis was generated by suturing endometrial tissue on the peritoneal wall of C57BL/6JNarl mice. The mice were subsequently treated with either GFW or current hormonal therapies or in combination for 28 days. RESULTS: Endometriosis development was inhibited by GFW, Gestrinone, Visanne, GFW + Gestrinone or GFW + medroxyprogesterone acetate (MPA). The expression of intercellular adhesion molecule 1 (ICAM-1) was inhibited by GFW, Gestrinone, MPA, Visanne, GFW + Gestrinone, GFW + MPA and GFW + Visanne. Vascular endothelial growth factor (VEGF) expression was inhibited by GFW, Gestrinone, Visanne, GFW + Gestrinone and GFW + MPA. Both ICAM-1- and VEGF-reducing effects of GFW were attenuated by western medicines. Administration of GFW, MPA, Visanne, GFW + MPA and GFW + Visanne also correspondingly reduced macrophage population in peritoneal fluid. GFW, MPA, Visanne, GFW + MPA and GFW + Visanne enhanced B-cell population in peritoneal fluid. CONCLUSION: The current study reveals the therapeutic effects of GFW on endometriosis. However, the combination of GFW and current hormonal therapies potentially impedes the efficacy of each individual agent in treating endometriosis.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Gestrinona / Acetato de Medroxiprogesterona / Molécula 1 de Adhesión Intercelular / Factor A de Crecimiento Endotelial Vascular / Endometriosis Límite: Animals Idioma: En Revista: Taiwan J Obstet Gynecol Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: China

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Medicamentos Herbarios Chinos / Gestrinona / Acetato de Medroxiprogesterona / Molécula 1 de Adhesión Intercelular / Factor A de Crecimiento Endotelial Vascular / Endometriosis Límite: Animals Idioma: En Revista: Taiwan J Obstet Gynecol Asunto de la revista: GINECOLOGIA / OBSTETRICIA Año: 2022 Tipo del documento: Article País de afiliación: Taiwán Pais de publicación: China