Paeonol Protects Against Methotrexate-Induced Nephrotoxicity <i>via</i> Upregulation of P-gp Expression and Inhibition of TLR4/NF-&#954;B Pathway.

Morsy, Mohamed A; El-Sheikh, Azza A K; Abdel-Hafez, Sara Mohamed Naguib; Kandeel, Mahmoud; Abdel-Gaber, Seham A

Paeonol Protects Against Methotrexate-Induced Nephrotoxicity via Upregulation of P-gp Expression and Inhibition of TLR4/NF-κB Pathway.

Morsy, Mohamed A; El-Sheikh, Azza A K; Abdel-Hafez, Sara Mohamed Naguib; Kandeel, Mahmoud; Abdel-Gaber, Seham A.

Afiliación

Morsy MA; Department of Pharmaceutical Sciences, College of Clinical Pharmacy, King Faisal University, Al-Ahsa, Saudi Arabia.
El-Sheikh AAK; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt.
Abdel-Hafez SMN; Department of Pharmacology, Faculty of Medicine, Minia University, Minia, Egypt.
Kandeel M; Department of Basic Sciences, College of Medicine, Princess Nourah Bint Abdulrahman University, Riyadh, Saudi Arabia.
Abdel-Gaber SA; Department of Histology and Cell Biology, Faculty of Medicine, Minia University, Minia, Egypt.

Front Pharmacol ; 13: 774387, 2022.

Article en En | MEDLINE | ID: mdl-35185559

Palabras clave

IL-1ß; KIM-1; NF-κB; P-glycoprotein; TLR4; methotrexate; nephrotoxicity; paeonol

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Front Pharmacol Año: 2022 Tipo del documento: Article País de afiliación: Arabia Saudita Pais de publicación: Suiza

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