Synthesis of α-Aryldiazophosphonates via a Diazo Transfer Reaction.
J Org Chem
; 87(5): 2748-2757, 2022 Mar 04.
Article
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| MEDLINE
| ID: mdl-35191306
ABSTRACT
The simple synthetic procedure for preparation of α-aryl-α-diazophosphonates via a diazo transfer reaction is proposed. Benzylphosphonates reacted with tosyl azide (TsN3) in the presence of potassium tert-butoxide (KOtBu) to afford diazophosphonates in a yield up to 79%. The proposed method is general. The reaction uses easily available starting materials, tolerates various functional groups, and may be applied for multi-gram scale synthesis.
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01-internacional
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MEDLINE
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En
Revista:
J Org Chem
Año:
2022
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Article