Fragment-Based Drug Discovery for Trypanosoma brucei Glycosylphosphatidylinositol-Specific Phospholipase C through Biochemical and WaterLOGSY-NMR Methods.

Ibrahim, Mohammed Auwal; Yamasaki, Tomoko; Furukawa, Koji; Yamasaki, Kazuhiko

Ibrahim, Mohammed Auwal; Yamasaki, Tomoko; Furukawa, Koji; Yamasaki, Kazuhiko.

Afiliación

Ibrahim MA; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 3058566, Japan and.
Yamasaki T; Department of Biochemistry, Ahmadu Bello University, Zaria, Kaduna 800001, Nigeria.
Furukawa K; Biomedical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 3058566, Japan and.
Yamasaki K; Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology (AIST), Tsukuba, Ibaraki 3058566, Japan.

J Biochem ; 171(6): 619-629, 2022 May 27.

Article en En | MEDLINE | ID: mdl-35191956

Asunto(s)

Trypanosoma brucei brucei; Tripanosomiasis Africana; Animales; Descubrimiento de Drogas; Glicosilfosfatidilinositol Diacilglicerol-Liasa/metabolismo; Ligandos; Simulación del Acoplamiento Molecular; Análisis Espectral; Trypanosoma brucei brucei/metabolismo; Tripanosomiasis Africana/tratamiento farmacológico; Tripanosomiasis Africana/parasitología; Fosfolipasas de Tipo C/metabolismo; Agua

Palabras clave

GPI anchor; antigenic variation; catalytic pocket; docking simulation; enzyme inhibition

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Trypanosoma brucei brucei / Tripanosomiasis Africana Tipo de estudio: Prognostic_studies Límite: Animals Idioma: En Revista: J Biochem Año: 2022 Tipo del documento: Article Pais de publicación: Reino Unido

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