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Serum homocysteine is associated with tubular interstitial lesions at the early stage of IgA nephropathy.
Li, Zizhen; Han, Qianqian; Ye, Hongbo; Li, Jiajia; Wei, Xiaona; Zhang, Rui; Huang, Qiuyan; Xu, Yanchun; Liu, Guanxian; Li, Bin; Yang, Qiongqiong.
Afiliación
  • Li Z; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Han Q; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Ye H; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Li J; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Wei X; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Zhang R; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Huang Q; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Xu Y; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Liu G; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China.
  • Li B; Clinical Trials Unit, The First Affiliated Hospital, Sun Yat-sen University, No.58 Zhongshan 2nd Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China. neolibin@126.com.
  • Yang Q; Department of Nephrology, Sun Yat-sen Memorial Hospital, Sun Yat-sen University, No.107 Yanjiang West Road, Yuexiu District, Guangzhou, Guangdong, People's Republic of China. yangqq@mail.sysu.edu.cn.
BMC Nephrol ; 23(1): 78, 2022 02 23.
Article en En | MEDLINE | ID: mdl-35196994
ABSTRACT

BACKGROUND:

The association between homocysteine (Hcy) and IgA nephropathy (IgAN) is not well understood. We aimed to investigate the relationship between Hcy and clinicopathologic features in IgAN patients.

METHODS:

A total of 337 IgAN patients and 150 sex- and age- matched healthy controls were enrolled in this single-center retrospective study. According to Hcy ≤ 10 µmol/L or > 10 µmol/L, patients were divided into low and high Hcy groups. Multivariate logistic regression was performed to explore the risk factors for elevated Hcy.

RESULTS:

Serum Hcy was higher in IgAN patients than in healthy controls [11.6 (9.1,15.3) vs. 8.8 (7.5,10.6) µmol/L, P < 0.001], unanimously in the subgroup of 156 patients with a normal estimated glomerular filtration rate (eGFR) (≥ 90 ml/min/1.73 m2) [9.9 (7.6,12.4) vs. 8.8 (7.5,10.6) µmol/L, P < 0.001]. Compared to the low Hcy group, serum creatinine (Scr), blood urine nitrogen (BUN), uric acid (UA), endocapillary hypercellularity (E) and tubular atrophy/interstitial fibrosis lesion (T) were higher in the high Hcy group. Hcy levels were positively correlated with Scr, BUN, UA, 24-h urine protein, and E and T lesions, but negatively correlated with eGFR and superoxide dismutase (SOD). In the subgroup with normal eGFR, patients with higher Hcy were persistent with higher Scr, BUN and T lesions. A multivariate logistic regression model showed that the risk of elevated Hcy in patients with pathological T increased by 2.87-fold. T lesions could better predict high Hcy, with an odds ratio (OR) of 14.20 in the subgroup with normal eGFR.

CONCLUSIONS:

Pathologic T was an independent risk factor associated with elevated Hcy, especially at the early stage of IgAN.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glomerulonefritis por IGA / Homocisteína / Túbulos Renales Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Glomerulonefritis por IGA / Homocisteína / Túbulos Renales Tipo de estudio: Diagnostic_studies / Observational_studies / Prognostic_studies / Risk_factors_studies Límite: Adult / Female / Humans / Male Idioma: En Revista: BMC Nephrol Asunto de la revista: NEFROLOGIA Año: 2022 Tipo del documento: Article