Identification of Nifurtimox and Chrysin as Anti-Influenza Virus Agents by Clinical Transcriptome Signature Reversion.

Xin, Yijing; Chen, Shubing; Tang, Ke; Wu, You; Guo, Ying

Xin, Yijing; Chen, Shubing; Tang, Ke; Wu, You; Guo, Ying.

Afiliación

Xin Y; Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Chen S; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Tang K; Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Wu Y; State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.
Guo Y; Department of Pharmacology, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, China.

Int J Mol Sci ; 23(4)2022 Feb 21.

Article en En | MEDLINE | ID: mdl-35216485

Asunto(s)

Antivirales/farmacología; Flavonoides/farmacología; Subtipo H1N1 del Virus de la Influenza A/efectos de los fármacos; Subtipo H3N2 del Virus de la Influenza A/efectos de los fármacos; Gripe Humana/tratamiento farmacológico; Nifurtimox/farmacología; Transcriptoma/efectos de los fármacos; Células A549; Línea Celular Tumoral; Humanos; Gripe Humana/genética

Palabras clave

chrysin; clinical transcriptome; drug combination; influenza A virus; network-based topological separation calculation; nifurtimox; transcriptome signature reversion

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Antivirales / Flavonoides / Gripe Humana / Subtipo H1N1 del Virus de la Influenza A / Subtipo H3N2 del Virus de la Influenza A / Transcriptoma / Nifurtimox Tipo de estudio: Diagnostic_studies / Prognostic_studies Límite: Humans Idioma: En Revista: Int J Mol Sci Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Suiza

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