[Impact of pregnancy on drug pharmacokinetics: What implication in clinical practice?] / Impact de la grossesse sur la pharmacocinétique des médicaments : quelles répercussions en pratique ?
Gynecol Obstet Fertil Senol
; 50(5): 422-425, 2022 05.
Article
en Fr
| MEDLINE
| ID: mdl-35219913
ABSTRACT
Physiological changes that occur during pregnancy in the maternal body can lead to alterations in the response to drugs in the mother. Pregnancy modifies the volume of distribution of drugs, their binding to plasma proteins, the activity of their metabolizing enzymes, and their elimination. However, to date, due to the dynamic and complex processes involved, adjustments to the dosage regimen during pregnancy remain impossible to standardize. Knowledge of these modifications will help to better understand the possible loss of drug efficacy during pregnancy, as well as anticipating the clinical and plasma monitoring of drugs with a low therapeutic margin.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Farmacocinética
/
Preparaciones Farmacéuticas
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
Fr
Revista:
Gynecol Obstet Fertil Senol
Año:
2022
Tipo del documento:
Article