Development of dynamic image analysis methods to measure vascularisation and syncytial nuclear aggregates in human placenta.
Placenta
; 120: 65-72, 2022 03 24.
Article
en En
| MEDLINE
| ID: mdl-35220183
ABSTRACT
Histological examination of the placenta significantly contributes to diagnosis in adverse birth outcomes. One challenge in image analysis is variation in staining intensity caused by batch variation. We investigated if dynamic threshold image analysis methods may increase accuracy. Placenta samples were stained for endothelial cells and syncytial nuclear aggregates and analysed in Qupath software. Dynamically setting the threshold resulted in data more similar to manual method data. The method is simple and effective at modelling the dynamic interpretation of variation in staining intensity achieved by manual methods. We anticipate dynamic methods could be used to enhance placental diagnosis.
Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Placenta
/
Células Endoteliales
Tipo de estudio:
Guideline
Límite:
Female
/
Humans
/
Pregnancy
Idioma:
En
Revista:
Placenta
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido