Stimuli responsive asymmetric catalysis by triggered pseudo-enantiomeric proligand release.
Org Biomol Chem
; 20(11): 2194-2199, 2022 03 16.
Article
en En
| MEDLINE
| ID: mdl-35234246
ABSTRACT
Complex stimuli responsive systems are the basis for molecular machines and computing. A dual psuedo-enantiomer system was conceived, where the combination of two 'switch-on' asymmetric catalytic cycles could be selectively triggered to afford an enantioenriched product. Two pseudo-enantiomeric proligands were designed and synthesised for selective activation by fluoride and alkaline phosphatase. The proligands were firstly incorporated into single proligand systems, and then into a dual proligand system, where enantioselectivity of up to 98 2 was achieved in the reduction of prochiral ketone following external stimulation.
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Idioma:
En
Revista:
Org Biomol Chem
Asunto de la revista:
BIOQUIMICA
/
QUIMICA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido