Preterm birth and infant diurnal cortisol regulation.
Arch Dis Child Fetal Neonatal Ed
; 107(5): 565-567, 2022 Sep.
Article
en En
| MEDLINE
| ID: mdl-35288450
ABSTRACT
BACKGROUND:
Hypothalamic-pituitary-adrenal (HPA) axis adaptation is a potential mechanism linking early life exposures with later adverse health. This study tested the hypothesis that preterm birth is associated with adaptation of diurnal cortisol regulation across infancy.METHODS:
A secondary analysis was conducted of saliva cortisol measured morning, midday and evening, monthly, across infancy, as part of a birth cohort conducted in Linköping, Sweden. Diurnal cortisol regulation of infants born extremely preterm (n=24), very preterm (n=27) and at term (n=130) were compared across infancy through random coefficients regression models.RESULTS:
Compared with infants born at term, infants born extremely preterm (-17.2%, 95% CI -30.7 to -1.2), but not very preterm (1.7%, 95% CI -14.1 to 20.4), had a flattened diurnal slope across infancy.CONCLUSIONS:
Extremely preterm birth is associated with a flattened diurnal slope in infancy. This pattern of cortisol regulation could contribute to adverse metabolic and neurodevelopmental phenotypes observed in this population.Palabras clave
Texto completo:
1
Colección:
01-internacional
Base de datos:
MEDLINE
Asunto principal:
Hidrocortisona
/
Nacimiento Prematuro
Límite:
Female
/
Humans
/
Newborn
Idioma:
En
Revista:
Arch Dis Child Fetal Neonatal Ed
Asunto de la revista:
PEDIATRIA
/
PERINATOLOGIA
Año:
2022
Tipo del documento:
Article
País de afiliación:
Reino Unido