Iron ion-coordinated carrier-free supramolecular co-nanoassemblies of dual DNA topoisomerase-targeting inhibitors for tumor suppression.

Guan, Jianhuan; Tan, Xiao; Jiao, Jian; Lai, Shuang; Zhang, Haotian; Kan, Qiming; He, Zhonggui; Sun, Mengchi; Sun, Jin

Guan, Jianhuan; Tan, Xiao; Jiao, Jian; Lai, Shuang; Zhang, Haotian; Kan, Qiming; He, Zhonggui; Sun, Mengchi; Sun, Jin.

Afiliación

Guan J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Tan X; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China; Department of Nursing, Nanyang Vocational College of Science and Technology, Nanyang, Henan, China.
Jiao J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Lai S; Department of Gastroenterology, First Affiliated Hospital of China Medical University, Shenyang, Liaoning, China.
Zhang H; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Kan Q; Department of Pharmacology, School of Life Science and Biopharmaceutics, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
He Z; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China.
Sun M; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China. Electronic address: smc_1990@aliyun.com.
Sun J; Wuya College of Innovation, Shenyang Pharmaceutical University, Shenyang, Liaoning, China. Electronic address: sunjin@syphu.edu.cn.

Acta Biomater ; 144: 121-131, 2022 05.

Article en En | MEDLINE | ID: mdl-35304322

Asunto(s)

Neoplasias de la Mama; Nanopartículas; Neoplasias de la Mama/tratamiento farmacológico; Línea Celular Tumoral; ADN-Topoisomerasas; Femenino; Humanos; Iones; Hierro/uso terapéutico; Nanopartículas/química; Recurrencia Local de Neoplasia/tratamiento farmacológico; Estudios Prospectivos; Quercetina; Inhibidores de Topoisomerasa/uso terapéutico

Palabras clave

Antitumor immune response; DNA topoisomerase II alpha (TOP-2A); Drug-likeness compounds; Intermolecular coordination interactions; Supramolecular co-nanoassemblies

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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Neoplasias de la Mama / Nanopartículas Tipo de estudio: Observational_studies Límite: Female / Humans Idioma: En Revista: Acta Biomater Año: 2022 Tipo del documento: Article País de afiliación: China Pais de publicación: Reino Unido

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