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Therapeutic treatment with an oral prodrug of the remdesivir parental nucleoside is protective against SARS-CoV-2 pathogenesis in mice.
Schäfer, Alexandra; Martinez, David R; Won, John J; Meganck, Rita M; Moreira, Fernando R; Brown, Ariane J; Gully, Kendra L; Zweigart, Mark R; Conrad, William S; May, Samantha R; Dong, Stephanie; Kalla, Rao; Chun, Kwon; Du Pont, Venice; Babusis, Darius; Tang, Jennifer; Murakami, Eisuke; Subramanian, Raju; Barrett, Kimberly T; Bleier, Blake J; Bannister, Roy; Feng, Joy Y; Bilello, John P; Cihlar, Tomas; Mackman, Richard L; Montgomery, Stephanie A; Baric, Ralph S; Sheahan, Timothy P.
Afiliación
  • Schäfer A; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Martinez DR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Won JJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Meganck RM; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Moreira FR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Brown AJ; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Gully KL; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Zweigart MR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Conrad WS; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • May SR; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Dong S; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
  • Kalla R; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Chun K; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Du Pont V; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Babusis D; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Tang J; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Murakami E; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Subramanian R; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Barrett KT; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Bleier BJ; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Bannister R; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Feng JY; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Bilello JP; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Cihlar T; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Mackman RL; Gilead Sciences Inc., Foster City, CA 94404, USA.
  • Montgomery SA; Department of Pathology and Laboratory Medicine, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Baric RS; Lineberger Comprehensive Cancer Center, University of North Carolina School of Medicine, Chapel Hill, NC 27599, USA.
  • Sheahan TP; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC 27599, USA.
Sci Transl Med ; 14(643): eabm3410, 2022 05 04.
Article en En | MEDLINE | ID: mdl-35315683
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Infecciones por Coronavirus / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos
Texto completo
Añadir a Mi BVS
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XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Profármacos / Infecciones por Coronavirus / Tratamiento Farmacológico de COVID-19 Tipo de estudio: Etiology_studies Límite: Animals / Humans Idioma: En Revista: Sci Transl Med Asunto de la revista: CIENCIA / MEDICINA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos Pais de publicación: Estados Unidos