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Long-Term Clearance and Biodistribution of Magnetic Nanoparticles Assessed by AC Biosusceptometry.
Soares, Guilherme A; Faria, João V C; Pinto, Leonardo A; Prospero, Andre G; Pereira, Gabriele M; Stoppa, Erick G; Buranello, Lais P; Bakuzis, Andris F; Baffa, Oswaldo; Miranda, José R A.
Afiliación
  • Soares GA; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Faria JVC; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Pinto LA; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Prospero AG; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Pereira GM; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Stoppa EG; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Buranello LP; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
  • Bakuzis AF; Institute of Physics, Federal University of Goiás, Goiânia 74690-900, GO, Brazil.
  • Baffa O; Faculty of Philosophy, Sciences and Letters at Ribeirão Preto, University of São Paulo, Ribeirão Preto 14040-900, SP, Brazil.
  • Miranda JRA; Department of Biophysics and Pharmacology, Institute of Biosciences, São Paulo State University-UNESP, Botucatu 18618-689, SP, Brazil.
Materials (Basel) ; 15(6)2022 Mar 14.
Article en En | MEDLINE | ID: mdl-35329574
ABSTRACT
Once administered in an organism, the physiological parameters of magnetic nanoparticles (MNPs) must be addressed, as well as their possible interactions and retention and elimination profiles. Alternating current biosusceptometry (ACB) is a biomagnetic detection system used to detect and quantify MNPs. The aims of this study were to evaluate the biodistribution and clearance of MNPs profiles through long-time in vivo analysis and determine the elimination time carried out by the association between the ACB system and MnFe2O4 nanoparticles. The liver, lung, spleen, kidneys, and heart and a blood sample were collected for biodistribution analysis and, for elimination analysis, and over 60 days. During the period analyzed, the animal's feces were also collectedd. It was possible to notice a higher uptake by the liver and the spleen due to their characteristics of retention and uptake. In 60 days, we observed an absence of MNPs in the spleen and a significant decay in the liver. We also determined the MNPs' half-life through the liver and the spleen elimination. The data indicated a concentration decay profile over the 60 days, which suggests that, in addition to elimination via feces, there is an endogenous mechanism of metabolization or possible agglomeration of MNPs, resulting in loss of ACB signal intensity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Materials (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Brasil

Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Idioma: En Revista: Materials (Basel) Año: 2022 Tipo del documento: Article País de afiliación: Brasil