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Identifying targets to prevent aminoglycoside ototoxicity.
Kim, Jinkyung; Hemachandran, Sriram; Cheng, Alan G; Ricci, Anthony J.
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  • Kim J; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Hemachandran S; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA.
  • Cheng AG; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: aglcheng@stanford.edu.
  • Ricci AJ; Department of Otolaryngology-Head and Neck Surgery, Stanford University School of Medicine, Stanford, CA 94305, USA; Department of Molecular and Cellular Physiology, Stanford University School of Medicine, Stanford, CA 94305, USA. Electronic address: aricci@stanford.edu.
Mol Cell Neurosci ; 120: 103722, 2022 05.
Article en En | MEDLINE | ID: mdl-35341941
ABSTRACT
Aminoglycosides are potent antibiotics that are commonly prescribed worldwide. Their use carries significant risks of ototoxicity by directly causing inner ear hair cell degeneration. Despite their ototoxic side effects, there are currently no approved antidotes. Here we review recent advances in our understanding of aminoglycoside ototoxicity, mechanisms of drug transport, and promising sites for intervention to prevent ototoxicity.
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ototoxicidad / Aminoglicósidos Límite: Humans Idioma: En Revista: Mol Cell Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos
Texto completo
Añadir a Mi BVS
Imprimir
XML
PubMed Links
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Texto completo: 1 Colección: 01-internacional Base de datos: MEDLINE Asunto principal: Ototoxicidad / Aminoglicósidos Límite: Humans Idioma: En Revista: Mol Cell Neurosci Asunto de la revista: BIOLOGIA MOLECULAR / NEUROLOGIA Año: 2022 Tipo del documento: Article País de afiliación: Estados Unidos